The efficacy of collagen-hydroxyapatite composite membrane on bone regeneration

科研成果详情

题名	The efficacy of collagen-hydroxyapatite composite membrane on bone regeneration
作者	Qiong Jin; Xiao-min Wang; Xiao-fei Wang; Xu-dong Li; Jian-feng Ma
发表日期	2011-02-01
发表期刊	Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To investigate the efficacy of a new collagen-hydroxyapatite (COL-HA) composite membrane on bone regeneration of SD rat cranial defects. Methods: Four defects were produced in the calvaria of 24 SD rats. The animals were divided into four groups: Empty defects without membrane (group 1); defects covered by COL-HA single-layer dense membranes (group 2); defects covered by COL-HA double-layer membranes (group 3); defects covered by Bio-Gide membranes (group 4). At 2, 4, 8 and 12 weeks after surgery, 6 rats were sacrificed and the following parameters were analyzed: Macroscopic observation, X-ray examination, descriptive histology, regenerate bone quantitative histology. Statistical analysis consisted of generalized linear models/factorial design analysis of variance and LSD-t test was performed. Results: Since two weeks after surgery, there were a small amount of bone regenerated in three groups except group 1. At 12 weeks after surgery, the opaque sclerous tissues filled with the defects in three groups, and residual membrane fragments still could be found. X-ray pictures showed the density of regenerate bone in group 3 and group 4 was closed to the original bone and greater than that of group 2. Quantitative analysis of regenerate bone showed that in initial stage, group 4 had more bone regeneration than the other groups (P < 0.05), and at 12 weeks after surgery the differences between group 4 and group 2/group 3 had no statistically significant. Conclusion: The COL-HA composite membranes can guide bone regeneration of rat cranial defects. The efficacy of bone regeneration of COL-HA double-layer membrane is superior to COL-HA single-layer dense membrane, because its property is more propitious to the adherence and proliferation of osteoblasts.
ISSN	1000-1182
卷号	29 期号:1 页码:21-6.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21427894
SCOPUSEID	2-s2.0-84933042046
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63435
专题	口腔医学院、附属口腔医院_口腔修复
作者单位	Dept. of Prosthodontics, Hospital of Stomatology, Wenzhou Medical College, Wenzhou 325027, China.
第一作者单位	口腔修复
第一作者的第一单位	口腔修复
推荐引用方式 GB/T 7714	Qiong Jin,Xiao-min Wang,Xiao-fei Wang,et al. The efficacy of collagen-hydroxyapatite composite membrane on bone regeneration[J]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology,2011,29(1):21-6..
APA	Qiong Jin, Xiao-min Wang, Xiao-fei Wang, Xu-dong Li, & Jian-feng Ma. (2011). The efficacy of collagen-hydroxyapatite composite membrane on bone regeneration. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 29(1), 21-6..
MLA	Qiong Jin,et al."The efficacy of collagen-hydroxyapatite composite membrane on bone regeneration".Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 29.1(2011):21-6..

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