Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou

科研成果详情

题名	Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou
作者	Xiao-ou Shan; Ying Wu; Jing Ye; Zhi-yong Ding; Cai Qian; Ai-hua Zhou
发表日期	2010
发表期刊	Zhonghua er ke za zhi = Chinese journal of pediatrics 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't
摘要	Objective: Sepsis remains a serious clinical problem because of high morbidity and mortality. The importance of Toll-like receptors (TLRs) for the induction of immune responses against sepsis was demonstrated in humans. The present study aimed to probe the gene polymorphisms of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg753Gln) in patients with sepsis among Chinese Han children in Wenzhou, and investigate the correlation with sepsis. Method: This study was conducted as a case-control study. Using polymerase chain reaction and DNA sequencing, gene polymorphisms of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg753Gln) in 59 children with sepsis, 38 children with severe sepsis (including 20 septic shock) and 57 healthy controls were analyzed. Hardy-Weinberg method of statistics was used to compare the frequency of genotypes alleles among three groups. Result: The mutant genotypes of TLR4 gene (Asp299Gly and Thr399Ile) were not found among sepsis, septic shock and control groups. In severe sepsis group, the Arg753Gln TLR2 polymorphism occurred in 2 out of 38 severe sepsis patients and both of the subjects with the TLR2 Arg753Gln polymorphism had fatal staphylococcal infections. Conclusion: TLR4 gene (Asp299Gly and Thr399Ile) polymorphisms may not be correlated with susceptibility to sepsis among Chinese Han children in Wenzhou. The fact that only 2 out of 38 severe sepsis patients had Arg753Gln TLR2 polymorphism suggests that a larger sample size is needed because of the rarity of the TLR2 allele among Chinese Han children in Wenzhou.
ISSN	0578-1310
卷号	48 期号:1 页码:15-8.
收录类别	PUBMED
URL	查看原文
PubMed ID	20441696
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63333
专题	附属第二医院_儿童急诊科
作者单位	Pediatric Emergency Department, Affiliated Yuying Children's Hospital of Wenzhou Medical College, Wenzhou 325003, China.
第一作者单位	附属第二医院_儿童急诊科
第一作者的第一单位	附属第二医院_儿童急诊科
推荐引用方式 GB/T 7714	Xiao-ou Shan,Ying Wu,Jing Ye,et al. Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou[J]. Zhonghua er ke za zhi = Chinese journal of pediatrics,2010,48(1):15-8..
APA	Xiao-ou Shan, Ying Wu, Jing Ye, Zhi-yong Ding, Cai Qian, & Ai-hua Zhou. (2010). Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou. Zhonghua er ke za zhi = Chinese journal of pediatrics, 48(1), 15-8..
MLA	Xiao-ou Shan,et al."Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou".Zhonghua er ke za zhi = Chinese journal of pediatrics 48.1(2010):15-8..