Efficacy of interleukin-10 for experimental autoimmune prostatitis

科研成果详情

题名	Efficacy of interleukin-10 for experimental autoimmune prostatitis
作者	Sen Yang; Hai-Qi Mu; Lei Zhang; Ying-He Chen
发表日期	2009-12-01
发表期刊	Zhonghua nan ke xue = National journal of andrology 影响因子和分区
语种	英语
原始文献类型	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
摘要	Objective: To study the efficacy of interleukin-10 (IL-10) in the treatment of experimental autoimmune prostatitis (EAP) and its effect on the expressions of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1 ) in EAP rat models. Methods: Thirty Wistar rats were equally and randomly divided into a control, an EAP and an IL-10 group. The controls were treated with normal saline, the EAP models were made by injection of purified prostate protein twice with immune adjuvant, and the IL-10 group included the EAP models subjected to IL-10 intervention. The infiltration of the inflammatory cells of the prostate tissue was detected by HE staining, the ultrastructure of the prostate cells and their surrounding cells observed by electron microscopy, and the levels of TNF-alpha and TGF-beta1 in the three groups determined by semi-quantitative RT-PCR assay. Results: The EAP group showed significantly severer inflammation and higher levels of TNF-alpha and TGF-beta1 in the prostate tissue than the controls (P < 0.05). The IL-10 group exhibited significantly lessened inflammatory infiltration of the prostate tissue and decreased levels of TNF-alpha and TGF-beta as compared with the EAP group (P < 0.05). Conclusion: IL-10 could relieve inflammatory infiltration of the prostate tissue and inhibit the expressions of TNF-alpha and TGF-beta1 in EAP rats, which is suggestive of its therapeutic efficacy for autoimmune prostatitis.
ISSN	1009-3591
卷号	15 期号:12 页码:1085-9.
收录类别	PUBMED
URL	查看原文
PubMed ID	20180418
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63215
专题	第二临床医学院，附属第二医院、育英儿童医院_外科学_泌尿外科
作者单位	Department of Urology, The Second Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_外科学_泌尿外科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_外科学_泌尿外科
推荐引用方式 GB/T 7714	Sen Yang,Hai-Qi Mu,Lei Zhang,et al. Efficacy of interleukin-10 for experimental autoimmune prostatitis[J]. Zhonghua nan ke xue = National journal of andrology,2009,15(12):1085-9..
APA	Sen Yang, Hai-Qi Mu, Lei Zhang, & Ying-He Chen. (2009). Efficacy of interleukin-10 for experimental autoimmune prostatitis. Zhonghua nan ke xue = National journal of andrology, 15(12), 1085-9..
MLA	Sen Yang,et al."Efficacy of interleukin-10 for experimental autoimmune prostatitis".Zhonghua nan ke xue = National journal of andrology 15.12(2009):1085-9..