Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts

科研成果详情

题名	Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts
作者	He-jing Xu; Ping-ping Lv; Li Zhu; Yang Wang; Yue-liang Shen; Ying-ying Chen
发表日期	2007-05-01
发表期刊	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Aim: Whether hemin, a heme oxygenase 1 (HO-1) inducer, reduces ischemia/reperfusion injury and whether NO synthase (NOS) and PKC are involved in the cardioprotective effects were investigated in the present study. Methods: The Langendorff model of isolated rat heart was used. The ventricular function, infarct size, LDH and CK during ischemia/reperfusion period were also observed. Results: (1) After intraperitoneal injection of hemin (50 mg/kg) for 24 h, COHb concentration in rat blood enhanced. He-min preconditioning prevented the increase in LVEDP, decrease in LVDP and +/- dP/dt(max) in the isolated ischemia/reperfusion (ischemia for 30 main and subsequent reperfusion for 2 h) rat hearts. The leakage of LDH and CK in the coronary effluent was significantly declined in hemin-treated rat hearts. And the infarct size was als reduced. (2) By using an inhibitor of NOS NG-nitro-L-arginine methyl ester before the administration of hemin could inhibit the protection induced by hemin. (3) Administration of an inhibitor of protein kinase C chelerythrine (1 mg/kg) before hemin preconditioning could also abolish the cardioprotection induced by hemin. Conclusion: These data suggest that the involvement of NO synthase and protein kinase C have been implicated in hemin-induced delayed cardioprotection in isolated rat hearts.
ISSN	1000-6834
卷号	23 期号:2 页码:180-3.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21179764
SCOPUSEID	2-s2.0-84860306202
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63065
专题	基础医学院（机能实验教学中心）_机能学系_生理学
作者单位	Department of Physiology, Wenzhou Medical College, Wenzhou 325027, China.
第一作者单位	基础医学院（机能实验教学中心）_机能学系_生理学
第一作者的第一单位	基础医学院（机能实验教学中心）_机能学系_生理学
推荐引用方式 GB/T 7714	He-jing Xu,Ping-ping Lv,Li Zhu,et al. Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts[J]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,2007,23(2):180-3..
APA	He-jing Xu, Ping-ping Lv, Li Zhu, Yang Wang, Yue-liang Shen, & Ying-ying Chen. (2007). Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 23(2), 180-3..
MLA	He-jing Xu,et al."Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts".Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 23.2(2007):180-3..