Effects of soybean isoflavone on born metabolism and morphology in animal model of osteoporosis rats

科研成果详情

题名	Effects of soybean isoflavone on born metabolism and morphology in animal model of osteoporosis rats
作者	Qing Yu; Yi-xiang Su; Wen-wei Wang; An-le Li; Cun-li Liu; Yi-long Wang; Wan-li Hu
发表日期	2007-07-01
发表期刊	Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To study the effects of soybean isoflavone (SI) on born metabolism and morphology in animal model of osteoporosis rats. Methods: All 70 female Sprague-Dawley (SD) rats were randomly divided into 7 groups according to the levels of total cholesterol (TC) in serum: hyper-lipoid group, estrogen group, low-dose SI group, middle-dose SI group, high-dose SI group, sham group and normal control groups. Bilateral ovaries were extirpated except sham and normal control groups. Except the rats in normal control group, the other rats were fed with high fat diet. Body weight was weighted ad unam vice per week. The estrogen, different dose of SI or deionized water were fed with intragastric administration for 12 weeks. Vena caudalis serum were collected after being ovariectomized, administered for 4 w, 8 w and killed. Serum alkaline phosphatase (AKP) activity and bone density were measured etc. Results: To interfere of estrogen and SI might recover AKP enzyme activity after its being ovariectomized. There almost sowed no differences between high dose SI intervention and estrogen on bone density and microstructure. Bone loss due to being ovariectomized was relieved after SI intervention. SI might protect cardiocyte myofilament and mitochondrial ultramicrostructure. There was mirror image in estrogen, high dose SI group resembling the normal control group, and there was obvious damage in hyper-lipoids group. Conclusion: There should be effects of high dose SI on bone metabolism and morphology in animal model of osteoporosis rats. Serum AKP enzyme activity and bone density should have significantly recovered, the serum level of calcium and phosphorus were maintained after high dose intervened but no significant effects for low dose of SI.
ISSN	0253-9624
卷号	41 期号:4 页码:299-303.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	17959054
SCOPUSEID	2-s2.0-65849287660
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63050
专题	仁济学院_环境与公共卫生学部
作者单位	Environmental and Public Health School, Wenzhou Medical College, Zhejiang 325035, China.
第一作者单位	仁济学院_环境与公共卫生学部
第一作者的第一单位	仁济学院_环境与公共卫生学部
推荐引用方式 GB/T 7714	Qing Yu,Yi-xiang Su,Wen-wei Wang,et al. Effects of soybean isoflavone on born metabolism and morphology in animal model of osteoporosis rats[J]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],2007,41(4):299-303..
APA	Qing Yu., Yi-xiang Su., Wen-wei Wang., An-le Li., Cun-li Liu., ... & Wan-li Hu. (2007). Effects of soybean isoflavone on born metabolism and morphology in animal model of osteoporosis rats. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 41(4), 299-303..
MLA	Qing Yu,et al."Effects of soybean isoflavone on born metabolism and morphology in animal model of osteoporosis rats".Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 41.4(2007):299-303..

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