Pharmacokinetics of a single bolus of propofol in chinese children of different ages

doi:10.1097/00000542-200601000-00006

科研成果详情

题名	Pharmacokinetics of a single bolus of propofol in chinese children of different ages
作者	Wang, Ning ShangGuan 1; Lian, QingQuan 1; Aarons, Leon 3; Matthews, Ivan 3; Wang, ZengShou2; Chen, XiaoLin 1; Freemantle, Nick 4; Smith, Fang Gao 5,6
发表日期	2006
发表期刊	Anesthesiology 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Background: There is no information about the pharmacokinetic profile of propofol in Chinese children younger than 3 yr. This study was designed to determine a complete pharmacokinetic profile of a single dose of propofol in Chinese children of different ages. Methods: Arterial blood samples were obtained from 35 children with an American Society of Anesthesiologist physical status of I or II at 2, 4, 6, 8, 10, 20, 30, 45, 60, 90, 120, and 180 min after a single bolus intravenous injection of propofol (3 mg/kg). The plasma concentrations of propofol were measured using high-performance liquid chromatography with an ultraviolet detector. A population model was used to estimate the pharmacokinetics of propofol. Results: A three-compartment pharmacokinetic model best described the pharmacokinetics of propofol. Clearance was 0.185 l/min, the volume of distribution of the central compartment was 7.41 l, the peripheral volumes of distribution were 54.6 and 7.2 l, and the intercompartmental clearances were 0.614 and 0.692 l/min for a child of the average weight of 13.7 kg. The half-lives were 2.67, 14.89, and 310.60 min. Covariate models were applied, and weight was found to be significant covariate for the clearance and volume of distribution parameters. No significant age effect could be demonstrated on clearance or volume of distribution parameters after weight was taken into account. Conclusions: This study supports the case that the pharmacokinetic properties of propofol do not differ substantially across Chinese children of different ages after weight has been accounted for.
ISSN	0003-3022
EISSN	0003-3022
卷号	104 期号:1 页码:27-32.
DOI	10.1097/00000542-200601000-00006
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	16394686
SCOPUSEID	2-s2.0-33644860307
自科自定义期刊分类	T3(B)类
通讯作者地址	[Smith, Fang Gao]Department of Anaesthesia and Intensive Care Medicine,Heart of England NHS Foundation Trust (Teaching),Birmingham Heartlands Hospital,United Kingdom
Scopus学科分类	Anesthesiology and Pain Medicine
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62974
专题	附属第二医院药学院（分析测试中心）_临床药学与药理系
通讯作者	Smith, Fang Gao
作者单位	1.Department of Anesthesiology; 2.Department of Pharmacology,WenZhou Medical College,China; 3.School of Pharmacy and Pharmaceutical Sciences,University of Manchester,United Kingdom; 4.Department of Primary Care and General Practice,University of Birmingham,United Kingdom; 5.Department of Anaesthesia and Intensive Care Medicine,Birmingham Heartlands Hospital,United Kingdom; 6.Department of Anaesthesia and Intensive Care Medicine,Heart of England NHS Foundation Trust (Teaching),Birmingham Heartlands Hospital,United Kingdom
推荐引用方式 GB/T 7714	Wang, Ning ShangGuan,Lian, QingQuan,Aarons, Leon,et al. Pharmacokinetics of a single bolus of propofol in chinese children of different ages[J]. Anesthesiology,2006,104(1):27-32..
APA	Wang, Ning ShangGuan., Lian, QingQuan., Aarons, Leon., Matthews, Ivan., Wang, ZengShou., ... & Smith, Fang Gao. (2006). Pharmacokinetics of a single bolus of propofol in chinese children of different ages. Anesthesiology, 104(1), 27-32..
MLA	Wang, Ning ShangGuan,et al."Pharmacokinetics of a single bolus of propofol in chinese children of different ages".Anesthesiology 104.1(2006):27-32..