The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients

科研成果详情

题名	The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients
作者	Cai-jiao Lu; Cai Lin; Jian-jun Xu; Peng Zhang; Guo-zhou Cao; Bao-shun Hong
发表日期	2004-08-01
发表期刊	Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 影响因子和分区
语种	英语
原始文献类型	English Abstract ; Journal Article ; Randomized Controlled Trial
摘要	Objective: To investigate the influence of combined supplementation of glutamine (Gln) and recombinant human growth hormone (rhGH) on the protein metabolism in severely burned patients. Methods: Sixty severely burned patients were enrolled in the study and were randomly divided into control (C, n = 20) and Gln with rhGH (Gln + rhGH, n = 20) groups. The patients in C group received glycine as the placebo, while those in Gln group took Gln orally in dose of 0.5 g kg(-1) d(-1) during 1-14 postburn days (PBDs). For the patients in Gln + rhGH group rhGH was administered subcutaneously in dose of 0.2 U kg(-1) d(-1) in addition to glutamine in same dosage beginning on the 7 PBD for 7 days. The plasma Gln concentration in the 3 groups of patients was determined on the 1st, 7th and 14th PBD and the plasma albumin level was determined on 14th and 21st PBD. The wound healing rate of the patients within 30 PBSs and the total hospital stay days were recorded. Results: The plasma Gln concentration in Gln + rhGH group of patients was evidently higher than that in C group after 7 PBD[(452.28 +/- 21.72) micromol/L vs(325.12 +/- 25.34) micromol/L, P < 0.05]. The plasma albumin level in Gln + rhGH group was obviously higher than that in C and Gln groups on the 21st PBD (P < 0.05). The wound healing rate in Gln + rhGH group was evidently higher than that in Gln and C groups on the 30th PBD (P < 0.05). The total hospital stay days in Gln + rhGH group were obviously less than that in C and Gln groups (P < 0.05 or 0.01). Conclusion: Combined administration of Gln and rhGH could be beneficial to the elevation of plasma Gln level in severely burned patients and the systemic protein synthesis was therefore enhanced and the wound healing rate was improved.
ISSN	1009-2587
卷号	20 期号:4 页码:220-2.
收录类别	PUBMED
URL	查看原文
PubMed ID	15447822
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62874
专题	附属第一医院_烧伤科
作者单位	Department of Burns, The First Affiliated Hospital of Wenzhou Medical College, Wen Zhou 325014, PR China.
第一作者单位	附属第一医院_烧伤科
第一作者的第一单位	附属第一医院_烧伤科
推荐引用方式 GB/T 7714	Cai-jiao Lu,Cai Lin,Jian-jun Xu,et al. The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients[J]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns,2004,20(4):220-2..
APA	Cai-jiao Lu, Cai Lin, Jian-jun Xu, Peng Zhang, Guo-zhou Cao, & Bao-shun Hong. (2004). The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 20(4), 220-2..
MLA	Cai-jiao Lu,et al."The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients".Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20.4(2004):220-2..

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