The clinical significance of expression of cyclooxygenase-2 gene in breast cancer

科研成果详情

题名	The clinical significance of expression of cyclooxygenase-2 gene in breast cancer
作者	Gui-long Guo; Zhen-xiang Yao; Jian Wu
发表日期	2003-10-10
发表期刊	Zhonghua yi xue za zhi 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To investigate the expressions of Cyclooxygenase-2 (COX-2) gene and protein in breast cancer, and understand its clinical significance. Methods: Reverse transcription-PCR, immunohistochemistry were used to assess the expression of COX-2 in 30 cancerous tissues, paired tissues adjacent to breast cancers and 6 normal tissues far from neoplasm. Results: Strong expression of COX-2 mRNA was detected in 86% of breast cancers with range of 0 - 1.180 with reference to the expression of beta-actin gene, and increased expression in paired tissues adjacent to cancers with range of 0 - 0.652, but nearly no expression in normal tissues. There were significant difference expression of COX-2 mRNA between cancers and paired tissues adjacent to cancers or normal tissues. Immunohistochemical analysis showed that COX-2 were expressed in 80% malignant epithelial cells, and 58% of paired tissues adjacent to cancers, no expression in normal tissues. Conclusion: Expressions of COX-2 gene and protein elevated not only in most human breast cancers, but also in paired tissues adjacent to cancers. Up-regulation of COX-2 is relatively early event in mammary carcinogenesis, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors may be useful in the chemoprevention and therapy of human breast cancer.
ISSN	0376-2491
卷号	83 期号:19 页码:1661-4.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	14642098
SCOPUSEID	2-s2.0-1542679195
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62723
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
作者单位	Department of Oncologic Surgery, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
推荐引用方式 GB/T 7714	Gui-long Guo,Zhen-xiang Yao,Jian Wu. The clinical significance of expression of cyclooxygenase-2 gene in breast cancer[J]. Zhonghua yi xue za zhi,2003,83(19):1661-4..
APA	Gui-long Guo, Zhen-xiang Yao, & Jian Wu. (2003). The clinical significance of expression of cyclooxygenase-2 gene in breast cancer. Zhonghua yi xue za zhi, 83(19), 1661-4..
MLA	Gui-long Guo,et al."The clinical significance of expression of cyclooxygenase-2 gene in breast cancer".Zhonghua yi xue za zhi 83.19(2003):1661-4..

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