Prognostic Nomogram for Patients with Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy

doi:10.1371/journal.pone.0134491

科研成果详情

题名	Prognostic Nomogram for Patients with Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy
作者	Shixiu Wu 1; Bing Xia 2; Fei Han 3; Ruifei Xie 2; Tao Song 4; Lixia Lu 3; Wei Yu 4; Xiaowu Deng 3; Qiancheng He 4; Cong Zhao 3; Conghua Xie 5
发表日期	2015-08-06
发表期刊	PloS one 影响因子和分区
语种	英语
原始文献类型	Article
摘要	This study was aimed to define possible predictors of overall survival in nasopharyngeal carcinoma (NPC). Patients were treated with intensity-modulated radiation therapy (IMRT), to establish an effective prognostic nomogram that could provide individualized predictions of treatment outcome in this setting. We reviewed the records of 533 patients with non-metastatic NPC who underwent IMRT with or without concurrent chemotherapy at the Department of Radiation Oncology of Sun Yat-Sen University from 2002 to 2009; none of these patients received induction or adjuvant chemotherapy. These data sets were used to construct a nomogram based on Cox regression. Nomogram performance was determined via a concordance index (C-index) and a calibration curve which was compared with the TNM staging system for NPC. The results were validated in an external cohort of 442 patients from the Department of Radiation Oncology of Wenzhou Medical College who were treated during the same period. Results showed that the greatest influence on survival were primary gross tumor volume, age, tumor stage and nodal stage (2002 Union for International Cancer Control [UICC] staging system), which were selected into the nomogram. The C-index of the nomogram for predicting survival was 0.748 (95%CI, 0.704-0.785), which was statistically higher than that of TNM staging system (0.684, P<0.001). The calibration curve exhibited agreement between nomogram-predicted and the actual observed probabilities for overall survival. In the validation cohort, the nomogram discrimination was superior to the TNM staging system (C-index: 0.768 vs 0.721; P = 0.026). In conclusion, the nomogram proposed in this study resulted in more-accurate prognostic prediction for patients with NPC after IMRT and compared favorably to the TNM staging system; this individualized information will aid in patient counseling and may be used for de-escalation trials in the future.
出版者	Public Library of Scienceplos@plos.org
ISSN	1932-6203
卷号	10 期号:8 页码:e0134491.
DOI	10.1371/journal.pone.0134491
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26248338
PMC记录号	PMC4527710
SCOPUSEID	2-s2.0-84941953300
Scopus学科分类	Multidisciplinary
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62699
专题	其他_浙江省肿瘤医院（浙江省癌症中心）
作者单位	1.Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, P. R. China; Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, Hubei, P. R. China; Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, P. R. China.; 2.Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, P. R. China.; 3.State Key Laboratory of Oncology in Southern China, Guangzhou, P. R. China; Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, P. R. China.; 4.Department of Radiation Oncology, Wenzhou Medical College Cancer Center, Wenzhou, Zhejiang, P. R. China.; 5.Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, P. R. China; Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, Hubei, P. R. China.
推荐引用方式 GB/T 7714	Shixiu Wu,Bing Xia,Fei Han,et al. Prognostic Nomogram for Patients with Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy[J]. PloS one,2015,10(8):e0134491..
APA	Shixiu Wu., Bing Xia., Fei Han., Ruifei Xie., Tao Song., ... & Conghua Xie. (2015). Prognostic Nomogram for Patients with Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy. PloS one, 10(8), e0134491..
MLA	Shixiu Wu,et al."Prognostic Nomogram for Patients with Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy".PloS one 10.8(2015):e0134491..