Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration

doi:10.1016/j.bbrc.2005.05.150

科研成果详情

题名	Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration
作者	Xiong Zhang; Wenjie Xie; Shen Qu; Tianhong Pan; Xiaotong Wang; Weidong Le
发表日期	2005-07-29
发表期刊	Biochemical and biophysical research communications 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
关键词	帕金森氏症神经元保护黑质恶化离子螯合剂蛋白酶体抑制剂
摘要	The cause of the neurodegenerative process in Parkinson's disease (PD) remains unclear, but evidence suggests that failure of the ubiquitin-proteasome system may play a major role in the pathogenesis of the disease. Iron is believed to be a key contributor to PD pathology by inducing aggregation of alpha-synuclein and by generating oxidative stress. Our present studies have shown that micro-injection of the proteasome inhibitor lactacystin into the substantia nigra (SN) of C57BL/6 mice causes significant loss of dopaminergic cells and induces intracellular inclusion body formation. We have also found that co-injection of the iron chelator desferrioxamine not only attenuates the lactacystin-induced dopamine neuron loss, but also reduces the presence of ubiquitin-positive intracellular inclusions in the SN, whereas use of iron-deficient diet has no such protective effects. These results may support that iron plays a key role in proteasome inhibitor-induced nigral pathology and that reducing iron reactivity may prevent dopaminergic neuron degeneration and reduce abnormal protein aggregation.
资助项目	DS NIH HHS[NINDS 043567];DS NIH HHS[NINDS 40370]
ISSN	0006-291X
卷号	333 期号:2 页码:544-9.
DOI	10.1016/j.bbrc.2005.05.150
页数	0
收录类别	PUBMED ; 万方
URL	查看原文
PubMed ID	15950935
引用统计	被引频次：73[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62693
专题	附属第二医院_神经内科
作者单位	Department of Neurology, The 2nd Affiliated Hospital to Wenzhou Medical College, China.
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xiong Zhang,Wenjie Xie,Shen Qu,et al. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration[J]. Biochemical and biophysical research communications,2005,333(2):544-9..
APA	Xiong Zhang, Wenjie Xie, Shen Qu, Tianhong Pan, Xiaotong Wang, & Weidong Le. (2005). Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochemical and biophysical research communications, 333(2), 544-9..
MLA	Xiong Zhang,et al."Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration".Biochemical and biophysical research communications 333.2(2005):544-9..