Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial

doi:10.3928/01477447-20100429-15

科研成果详情

题名	Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial
作者	Lin, Lina 1; Wang, Liangrong1; Bai, Yu 1; Zheng, Liupu1; Zhao, Xiyue1; Xiong, Xiangqing1; Jin, Lida1; Ji, Wei 1; Wang, Wantie2
发表日期	2010-06-09
发表期刊	Orthopedics 影响因子和分区
语种	英语
原始文献类型	Article
摘要	The tourniquet has been considered as a recognized cause of limb ischemia/reperfusion injury in orthopedic surgery resulting in a transient neutrophil, monocyte activation, and enhanced neutrophil transendothelial migration with potential remote tissue injury. This study investigated the effect of unilateral tourniquet application within a safe time limit on pulmonary function and the roles of lipid peroxidation and systemic inflammatory response. Thirty patients undergoing unilateral lower extremity surgery with or without tourniquet were equally divided into a control group with no tourniquet (Group C) and a tourniquet (Group T). Arterial partial pressure of oxygen (P(a)O(2)), arterial-alveolar oxygen tension ratio (a/A ratio), alveolar-arterial oxygen difference (A-aDO(2)) and respiratory index, plasma malondialdehyde, serum interleukin (IL) -6 and IL-8 levels were measured immediately before and 1 hour after tourniquet inflation/operation beginning, 0.5, 2, 6, and 24 hours after tourniquet deflation/operation ending. The results represented no significant changes in Group C with regard to either blood gas variables or levels of circulating mediators, while blood gas variable changes of greater A-aDO(2) and respiratory index and lower PaO2 and a/A ratio were shown at 6 hours following tourniquet deflation. The levels of malondialdehyde, IL-6, and IL-8 were increased over baseline values from 2 to 24 hours following tourniquet deflation in Group T. We concluded that tourniquet application within a safe time limit may cause pulmonary gas exchange impairment several hours after tourniquet deflation, where lipid peroxidation and systemic inflammatory response may be involved.
ISSN	0147-7447
EISSN	1938-2367
卷号	33 期号:6 页码:395
DOI	10.3928/01477447-20100429-15
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	20806768
SCOPUSEID	2-s2.0-77953643969
通讯作者地址	[Wang, Wantie]Department of Pathophysiology,Wenzhou Medical College,University-town,China
Scopus学科分类	Surgery;Orthopedics and Sports Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62663
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_麻醉科
通讯作者	Wang, Wantie
作者单位	1.Department of Anesthesiology,Wenzhou Medical College,China; 2.Department of Pathophysiology,Wenzhou Medical College,University-town,China
第一作者单位	麻醉科
通讯作者单位	温州医科大学
第一作者的第一单位	麻醉科
推荐引用方式 GB/T 7714	Lin, Lina,Wang, Liangrong,Bai, Yu,et al. Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial[J]. Orthopedics,2010,33(6):395.
APA	Lin, Lina., Wang, Liangrong., Bai, Yu., Zheng, Liupu., Zhao, Xiyue., ... & Wang, Wantie. (2010). Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial. Orthopedics, 33(6), 395.
MLA	Lin, Lina,et al."Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial".Orthopedics 33.6(2010):395.