Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-kappa B signaling activation in the heart

doi:10.1016/j.yjmcc.2015.10.010

科研成果详情

题名	Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-kappa B signaling activation in the heart
作者	Cong, Weitao1; Ruan, Dandan 1,2; Xuan, Yuanhu1; Niu, Chao1; Tao, Youli 1; Wang, Yang3; Zhan, Kungao4; Cai, Lu 5; Jin, Litai1; Tan, Yi1
发表日期	2015-12
发表期刊	JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Catalase NF-kappa B Nitration Diabetes Cardiomyopathy
其他关键词	OXIDATIVE STRESS ; MITOCHONDRIAL RESPIRATION ; RAT HIPPOCAMPUS ; DYSFUNCTION ; NITRATION ; ATP ; INFLAMMATION ; APOPTOSIS ; SURVIVAL ; TYPE-1
摘要	Catalase is an antioxidant enzyme that specifically catabolizes hydrogen peroxide (H2O2). Overexpression of catalase via a heart-specific promoter (CAT-TG) was reported to reduce diabetes-induced accumulation of reactive oxygen species (ROS) and further prevent diabetes-induced pathological abnormalities, including cardiac structural derangement and left ventricular abnormity in mice. However, the mechanism by which catalase overexpression protects heart function remains unclear. This study found that activation of a ROS-dependent NF-kappa B signaling pathway was downregulated in hearts of diabetic mice overexpressing catalase. In addition, catalase overexpression inhibited the significant increase in nitration levels of key enzymes involved in energy metabolism, including alpha-oxoglutarate dehydrogenase E1 component (alpha-KGD) and ATP synthase alpha and beta subunits (ATP-alpha and ATP-beta). To assess the effects of the NF-kappa B pathway activation on heart function, Bay11-7082, an inhibitor of the NF-kappa B signaling pathway, was injected into diabetic mice, protecting mice against the development of cardiac damage and increased nitrative modifications of key enzymes involved in energy metabolism. In conclusion, these findings demonstrated that catalase protects mouse hearts against diabetic cardiomyopathy, partially by suppressing NF-kappa B-dependent inflammatory responses and associated protein nitration. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371753, 81300171, 31300657]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ13H020005]; Zhejiang Key Health Science and Technology Project [WKJ2014-2-015]; Technology Program of Wenzhou [Y20140737, Y20130156]
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0022-2828
EISSN	1095-8584
卷号	89 期号:Pt B 页码:314-325
DOI	10.1016/j.yjmcc.2015.10.010
页数	12
WOS类目	Cardiac & Cardiovascular Systems ; Cell Biology
WOS研究方向	Cardiovascular System & Cardiology ; Cell Biology
WOS记录号	WOS:000367417400025
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26456065
SCOPUSEID	2-s2.0-84952715016
通讯作者地址	[Jin, Litai]School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Molecular Biology;Cardiology and Cardiovascular Medicine
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5871
专题	药学院（分析测试中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院基础医学院（机能实验教学中心）_形态学系_组织胚胎学
通讯作者	Jin, Litai
作者单位	1.School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325000,China; 2.The Health Examination Center,The 117th Hospital of Chinese People's Liberation Army,Hangzhou,310013,China; 3.Department of Histology and Embryology,Institute of Neuroscience,Wenzhou Medical University,Wenzhou,325000,China; 4.The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.The First Hospital of Jilin University,Changchun,130021,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Cong, Weitao,Ruan, Dandan,Xuan, Yuanhu,et al. Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-kappa B signaling activation in the heart[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,2015,89(Pt B):314-325.
APA	Cong, Weitao., Ruan, Dandan., Xuan, Yuanhu., Niu, Chao., Tao, Youli., ... & Tan, Yi. (2015). Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-kappa B signaling activation in the heart. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 89(Pt B), 314-325.
MLA	Cong, Weitao,et al."Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-kappa B signaling activation in the heart".JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 89.Pt B(2015):314-325.