The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain

doi:10.21037/apm-20-1900

科研成果详情

题名	The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain
作者	Cong, Wenjie1; Peng, Yu2; Meng, Bojun 3; Jia, Xiang 4; Jin, Zhenzhen 1
发表日期	2021-01
发表期刊	ANNALS OF PALLIATIVE MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Electroacupuncture (EA) chronic pain depression-like behaviors 5-hydroxytryptamine (5-HT) brain-derived neuropathic factor (BDNF) anterior cingulate cortex (ACC) spinal cord neuropathic pain
其他关键词	ACTIVATION ; BDNF ; ASSOCIATIONS ; ACUPUNCTURE ; ANXIETY ; STRESS ; MEMORY ; MODEL ; MICE
摘要	Background: Recently, the role of electroacupuncture (EA) in chronic neuropathic pain has been widely reported. However, its specific mechanisms and ability to mitigate depression-like behaviors induced by chronic pain remains unclear. This study aims to determine the analgesic and antidepressant effect of EA. Methods: The mechanical threshold sensory and hot plate tests were employed to measure mechanical hyperalgesia and thermal allodynia. The open filed test (OFT) and tail suspension test (TST) were used to observe depressive behavior in chronic constrictive injury (CCI) mice. In addition, the 5-hydroxytryptamine (5-HT) and brain-derived neuropathic factor (BDNF) levels in the anterior cingulate cortex (ACC) and spinal cord were assessed using enzyme-linked immunosorbent assay (ELISA). The protein levels of cAMP-response element-binding protein (CREB) and BDNF in the ACC were analyzed by western blotting. Results: Our results demonstrated that EA treatment could increase the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) values. Also, EA improved the CCI-induced depression-like behaviors, and significantly reversed the down-regulation of BDNF and 5-HT expression in the ACC and spinal cord after CCI. Furthermore, EA regulated the level of CREB in the ACCs and spinal cords of mice. Conclusions: These results suggested that the analgesic and antidepressant effect of EA is achieved through regulating CREB-5-HT/BDNF signaling pathway in the ACCs and spinal cords of mice.
出版者	AME PUBL CO
出版地	SHATIN
ISSN	2224-5820
EISSN	2224-5839
卷号	10 期号:1 页码:104-113
DOI	10.21037/apm-20-1900
页数	10
WOS类目	Health Care Sciences & Services
WOS研究方向	Health Care Sciences & Services
WOS记录号	WOS:000614549600012
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33474954
SCOPUSEID	2-s2.0-85100007089
通讯作者地址	[Jin, Zhenzhen]Department of Acupuncture and Physiotherapy,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Advanced and Specialized Nursing;Anesthesiology and Pain Medicine
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5843
专题	附属第一医院
通讯作者	Jin, Zhenzhen
作者单位	1.Department of Acupuncture and Physiotherapy,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Pain Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Rehabilitation,Tongxiang First People’s Hospital,Jiaxing,China; 4.Department of Rehabilitation,Taizhou Central Hospital,Taizhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Cong, Wenjie,Peng, Yu,Meng, Bojun,et al. The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain[J]. ANNALS OF PALLIATIVE MEDICINE,2021,10(1):104-113.
APA	Cong, Wenjie, Peng, Yu, Meng, Bojun, Jia, Xiang, & Jin, Zhenzhen. (2021). The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain. ANNALS OF PALLIATIVE MEDICINE, 10(1), 104-113.
MLA	Cong, Wenjie,et al."The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain".ANNALS OF PALLIATIVE MEDICINE 10.1(2021):104-113.