Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats

doi:10.1016/j.bbrc.2010.06.086

科研成果详情

题名	Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats
作者	Li, Xiao-Li1,2; Lv, Jin 1,2; Xi, Na-Na 1,2; Wang, Tan 1,2; Shang, Xiao-Feng 1,2; Xu, Hui-Qin1,2; Han, Zhao1,2; O'Byrne, Kevin Thomas 3; Li, Xiao-Feng 3; Zheng, Rong-Yuan1,2
发表日期	2010-07-23
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Encephalomyelitis IL-17 IFN-gamma IL-10 Lipopolysaccharide Rat
其他关键词	EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; MYELIN BASIC-PROTEIN ; EARLY-LIFE EXPOSURE ; MULTIPLE-SCLEROSIS ; T-CELLS ; ANTIGEN PRESENTATION ; INTERFERON-GAMMA ; CRUCIAL ROLE ; ASTROCYTES ; INDUCTION
摘要	Early-life exposure to bacterial endotoxin (lipopolysaccharide, LPS) affects the susceptibility to a variety of systemic organic inflammation in adulthood. To determine the long-term effects of neonatal LPS exposure on inflammatory responses in the central nervous system (CNS) in adulthood, we examined the effects on the development of experimental autoimmune encephalomyelitis (EAE) in adult rats as well as the potential regulatory immune mechanisms involved. The results showed that neonatal LPS exposure significantly reduced the morbidity (p < 0.01) and severity (p < 0.05) of EAE in adult rats, and decreased inflammatory cell infiltration and demyelination in the CNS compared with neonatal saline controls (p < 0.05). Neonatal LPS-treated animals showed reduced activation of microglia and astrocytes, as detected by immunocytochemistry, accompanied by down-regulation of the pro-inflammatory cytokines interleukin-17 and interferon-gamma but up-regulation of anti-inflammatory cytokine interleukin-10 in the CNS (p < 0.05). At the same time, cerebrum mRNA levels of the transcription factors T-bet and ROR gamma t were lower in neonatal LPS-compared with saline- treated animals (p < 0.05) accompanied with increased STAT-6 and Foxp3 levels in the neonatal LPS-treated group (p < 0.05). These findings suggest that early-life exposure to LPS could provide an important neuroprotective effect on the development of EAE in adult rats due to modulation of inflammatory responses in the CNS. (C) 2010 Elsevier Inc. All rights reserved.
资助项目	Wenzhou Medical College [XNK07001]; Natural Science Funding of Zhejiang Province [Y2090864]; Building Funding of Zhejiang Key Subject (Pharmacology and Biochemical Pharmaceutics) in PR China; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F007396/1] Funding Source: UKRI; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F007396/1] Funding Source: researchfish
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
出版地	SAN DIEGO
ISSN	0006-291X
EISSN	1090-2104
卷号	398 期号:2 页码:302-308
DOI	10.1016/j.bbrc.2010.06.086
页数	7
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000280458400026
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	20599716
SCOPUSEID	2-s2.0-77955052028
通讯作者地址	[Zheng, Rong-Yuan]Wenzhou Med Coll, Dept Neurol, Affiliated Hosp 1, 2 Fuxue Lane, Wenzhou City 325000, Zhejiang, Peoples R China.
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5831
专题	药学院（分析测试中心）_实验神经生物研究所
通讯作者	Zheng, Rong-Yuan
作者单位	1.Wenzhou Med Coll, Dept Neurol, Affiliated Hosp 1, Wenzhou City 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Coll, Res Inst Expt Neurobiol, Wenzhou City 325000, Zhejiang, Peoples R China; 3.Kings Coll London, Div Reprod & Endocrinol, London SE1 1UL, England
第一作者单位	药学院（分析测试中心）_实验神经生物研究所
推荐引用方式 GB/T 7714	Li, Xiao-Li,Lv, Jin,Xi, Na-Na,et al. Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,398(2):302-308.
APA	Li, Xiao-Li., Lv, Jin., Xi, Na-Na., Wang, Tan., Shang, Xiao-Feng., ... & Zheng, Rong-Yuan. (2010). Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 398(2), 302-308.
MLA	Li, Xiao-Li,et al."Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 398.2(2010):302-308.