Prognostic value of extra-vascular lung water index and pulmonary vascular permeability index in patients with ARDS

科研成果详情

题名	Prognostic value of extra-vascular lung water index and pulmonary vascular permeability index in patients with ARDS
作者	Danqin Liu; Weixian Zeng; Wangfeng Zhou; Yuanrong Dai
发表日期	2015-11-24
发表期刊	Zhonghua yi xue za zhi 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective:To investigate the correlation of the extra-vascular lung water index (EVLWI) and the pulmonary vascular permeability index (PVPI) with disease severity and their prognostic value in patients with acute respiratory distress syndrome (ARDS). Methods:A total of 44 patients with ARDS from October 2012 to June 2014 admitted in the Second Affiliated Hospital of Wenzhou Medical University were recruited in this study. According to the severity, patients were divided into three groups (Mild group, Moderate group and Severe group); the acute physiology and chronic health evaluation system II score (APACHE II), the lung injury score (LIS), the pulse contour curve continuous cardiac output (PiCCO) and other clinical indicators were respectively monitored in the period of 24, 48, 72 hrs after admission; then the correlation of EVLWI, PVPI and oxygenation index (OI) among groups were analyzed; According to the prognosis, patients were divided into the survival group and the death group, both given the univariate and multivariate Logistic regression analysis; EVLWI, PVPI, APACHE II score, LIS and lactic acid were admitted into the receiver operating characteristic (ROC) curve analysis, and the prognosis was evaluated respectively. Results:With the increase of disease severity, LIS and lactic acid gradually increased, the difference was significant among the three groups of Mild, Moderate and Severe (P<0.05). And the APACHE II score also increased gradually with the severity, but the difference was statistically significant only between the Mild group and the Severe group (P<0.01). And likewise, mild, moderate, severe ARDS patients had 1, 6, 9 cases of death, respectively. The 28-day mortality rate increased gradually after admission, with a significant difference between the Mild group and the Severe group (P<0.05). When all the 44 patients of three severities (during the 24 hrs period and during the 72 hrs period) were compared, the OI gradually decreased with the increase of severity of ARDS, while EVLWI and PVPI ascended, and differences between any two groups were statistically significant (P<0.05). In addition, there was a significant negative correlation between EVLWI and OI or between PVPI and OI (r=-0.666, -0.763, all P<0.01), and a significant positive correlation between EVLWI and PVPI, the APACHE II score or LIS (r=0.929, 0.895, 0.661, all P<0.01). Besides, OI was a predictive protection factor of ARDS, whereas lactic acid, EVLWI and PVPI were risk factors. Multivariate Logistic regression analysis showed that EVLWI and lactic acid were risk factors for ARDS death (all P<0.05). ROC curve analysis results suggested EVLWI and lactic acid were risk factors, (odd ratio (OR)> 1, and 95%CI: 1.071-5.201, 5.201-99.852, all P<0.05). Conclusion:EVLWI, PVPI were positively correlated with the severity of ARDS illness; EVLWI can be used as an independent risk factor for forecasting ARDS death, jointing EVLWI with PVPI could improve the accuracy of ARDS death forecasting.
ISSN	0376-2491
卷号	95 期号:44 页码:3602-6.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26813373
SCOPUSEID	2-s2.0-84979621153
Scopus学科分类	Medicine (all)
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55988
专题	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
作者单位	Respiratory Medicine, the 2nd Affiliated Hospital and Yuying Children&s Hospital of Wenzhou Medical University, Wenzhou 325027, China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
推荐引用方式 GB/T 7714	Danqin Liu,Weixian Zeng,Wangfeng Zhou,et al. Prognostic value of extra-vascular lung water index and pulmonary vascular permeability index in patients with ARDS[J]. Zhonghua yi xue za zhi,2015,95(44):3602-6..
APA	Danqin Liu, Weixian Zeng, Wangfeng Zhou, & Yuanrong Dai. (2015). Prognostic value of extra-vascular lung water index and pulmonary vascular permeability index in patients with ARDS. Zhonghua yi xue za zhi, 95(44), 3602-6..
MLA	Danqin Liu,et al."Prognostic value of extra-vascular lung water index and pulmonary vascular permeability index in patients with ARDS".Zhonghua yi xue za zhi 95.44(2015):3602-6..