题名 | Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease |
作者 | |
发表日期 | 2014-11-22 |
发表期刊 | American journal of translational research 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | ER stress FGF1 parkinson’s disease α-synuclein. |
其他关键词 | FIBROBLAST-GROWTH-FACTOR ; ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; SPINAL-CORD-INJURY ; ALPHA-SYNUCLEIN ; OXIDATIVE INJURY ; SUBSTANTIA-NIGRA ; NEURONS ; DEATH ; ACTIVATION |
摘要 | Parkinson's disease (PD) is a degenerative disorder of the central nervous system and is characterized by motor system disorders resulting in loss of dopamine producing brain cells. Acidic fibroblast growth factor, also called FGF1, promotes the survival of neurons. The aims of the present study were to confirm FGF1 could protect neurons cultures from 6-hydroxydopamine (6-OHDA) toxicity in vitro and in vivo. Our results demonstrated FGF1 administration improved the motor function recovery, increased the TH-positive neurons survival and up-regulated the levels of neurotransmitters in PD rats. Meanwhile, FGF1 prevents the death of DA neuron at least in part by reducing the levels of α-synuclein and ER stress. The administration of FGF1 activated downstream signals PI3K/Akt and ERK1/2. In conclusion, FGF1 diminished α-synuclein neurotoxicity by down regulating ER stress mediators and the level of apoptosis, and these effects may underlying the activation of the PI3K/Akt and ERK1/2 signal pathway. |
资助项目 | National Natural Science Funding of China [81372112, 81302775, 81260202]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents; Zhejiang Provincial Natural Science Foundation of China [Y2090834]; Zhejiang Provincial Project of Key Scientific Group [2012R10042] |
出版者 | E-CENTURY PUBLISHING CORP |
ISSN | 1943-8141 |
卷号 | 6期号:6页码:664-77. |
页数 | 14 |
WOS类目 | Oncology ; Medicine, Research & Experimental |
WOS研究方向 | Oncology ; Research & Experimental Medicine |
WOS记录号 | WOS:000348299700004 |
收录类别 | PUBMED ; SCIE |
URL | 查看原文 |
PubMed ID | 25628778 |
PMC记录号 | PMC4297335 |
通讯作者地址 | [Xiao, Jian]Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325035, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/55986 |
专题 | 其他_附属慈溪医院(慈溪市人民医院) 其他_附属舟山医院(舟山医院) 药学院(分析测试中心)_生物制药系_生物制药工程 |
通讯作者 | Xiao, Jian |
作者单位 | 1.Wenzhou Med Univ, Cixi Peoples Hosp, Dept Neurosurg, Ningbo 315300, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Zhoushan Hosp, Dept Neurol, Zhoushan 316000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325035, Zhejiang, Peoples R China; 4.Gangnan Med Univ, Affiliated Hosp 1, Dept Anesthesia, Ganzhou 341000, Jiangxi, Peoples R China |
第一作者单位 | 其他_附属慈溪医院(慈溪市人民医院) |
通讯作者单位 | 药学院(分析测试中心)_生物制药系_生物制药工程 |
第一作者的第一单位 | 其他_附属慈溪医院(慈溪市人民医院) |
推荐引用方式 GB/T 7714 | Wei, Xiaojie,He, Songbin,Wang, Zhouguang,et al. Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease[J]. American journal of translational research,2014,6(6):664-77.. |
APA | Wei, Xiaojie., He, Songbin., Wang, Zhouguang., Wu, Jiamin., Zhang, Jinjing., ... & Xiao, Jian. (2014). Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease. American journal of translational research, 6(6), 664-77.. |
MLA | Wei, Xiaojie,et al."Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease".American journal of translational research 6.6(2014):664-77.. |
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