Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson&#x27;s disease

科研成果详情

题名	Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease
作者	Wei, Xiaojie1; He, Songbin 2; Wang, Zhouguang 3; Wu, Jiamin3; Zhang, Jinjing 3; Cheng, Yi 3; Yang, Jie 3; Xu, Xinlong1; Chen, Zaifeng1; Ye, Junmin 4; Chen, Li 4; Lin, Li 3; Xiao, Jian 3
发表日期	2014-11-22
发表期刊	American journal of translational research 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ER stress FGF1 parkinson’s disease α-synuclein.
其他关键词	FIBROBLAST-GROWTH-FACTOR ; ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; SPINAL-CORD-INJURY ; ALPHA-SYNUCLEIN ; OXIDATIVE INJURY ; SUBSTANTIA-NIGRA ; NEURONS ; DEATH ; ACTIVATION
摘要	Parkinson's disease (PD) is a degenerative disorder of the central nervous system and is characterized by motor system disorders resulting in loss of dopamine producing brain cells. Acidic fibroblast growth factor, also called FGF1, promotes the survival of neurons. The aims of the present study were to confirm FGF1 could protect neurons cultures from 6-hydroxydopamine (6-OHDA) toxicity in vitro and in vivo. Our results demonstrated FGF1 administration improved the motor function recovery, increased the TH-positive neurons survival and up-regulated the levels of neurotransmitters in PD rats. Meanwhile, FGF1 prevents the death of DA neuron at least in part by reducing the levels of α-synuclein and ER stress. The administration of FGF1 activated downstream signals PI3K/Akt and ERK1/2. In conclusion, FGF1 diminished α-synuclein neurotoxicity by down regulating ER stress mediators and the level of apoptosis, and these effects may underlying the activation of the PI3K/Akt and ERK1/2 signal pathway.
资助项目	National Natural Science Funding of China [81372112, 81302775, 81260202]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents; Zhejiang Provincial Natural Science Foundation of China [Y2090834]; Zhejiang Provincial Project of Key Scientific Group [2012R10042]
出版者	E-CENTURY PUBLISHING CORP
ISSN	1943-8141
卷号	6 期号:6 页码:664-77.
页数	14
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000348299700004
收录类别	PUBMED ; SCIE
URL	查看原文
Pubmed记录号	25628778
PMC记录号	PMC4297335
通讯作者地址	[Xiao, Jian]Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325035, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55986
专题	其他_附属慈溪医院（慈溪市人民医院）其他_附属舟山医院（舟山医院）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Xiao, Jian
作者单位	1.Wenzhou Med Univ, Cixi Peoples Hosp, Dept Neurosurg, Ningbo 315300, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Zhoushan Hosp, Dept Neurol, Zhoushan 316000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325035, Zhejiang, Peoples R China; 4.Gangnan Med Univ, Affiliated Hosp 1, Dept Anesthesia, Ganzhou 341000, Jiangxi, Peoples R China
第一作者单位	附属慈溪医院（慈溪市人民医院）
通讯作者单位	生物制药工程
第一作者的第一单位	附属慈溪医院（慈溪市人民医院）
推荐引用方式 GB/T 7714	Wei, Xiaojie,He, Songbin,Wang, Zhouguang,et al. Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease[J]. American journal of translational research,2014,6(6):664-77..
APA	Wei, Xiaojie., He, Songbin., Wang, Zhouguang., Wu, Jiamin., Zhang, Jinjing., ... & Xiao, Jian. (2014). Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease. American journal of translational research, 6(6), 664-77..
MLA	Wei, Xiaojie,et al."Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease".American journal of translational research 6.6(2014):664-77..