Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β 1/Smad3 pathway

科研成果详情

题名	Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β 1/Smad3 pathway
作者	Wang, Hong-Wei 2; Chen, Yi-He1; Chen, Yan-Yan 5; Huang, Wei 4; Zhu, Xian-Dong 2; Ni, Fu-Biao 2; Wu, Guo-Di 6; Xu, Zi-Qiang3; Huang, Zhou-Qing1; Chen, Bi-Cheng2; Xiao, Fang-Yi1
发表日期	2018-08-15
发表期刊	American journal of translational research 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Diabetes mellitus TGF-β1/Smad3 signaling cardiac fibrosis islet transplantation.
其他关键词	MYOCARDIAL FIBROSIS ; PANCREAS TRANSPLANTATION ; OXIDATIVE STRESS ; HEART-FAILURE ; CARDIOMYOPATHY ; CELL ; FIBROBLAST ; INFLAMMATION ; NEPHROPATHY ; DYSFUNCTION
摘要	Although islet transplantation has been identified as a promising endocrine replacement treatment for patient with diabetes mellitus (DM), it still remains unclear whether islet transplantation can inhibit the diabetic-induced myocardial injury and subsequent adverse ventricular remodeling. Here, we sought to explore the molecular mechanism underlying the cardioprotective effect of islet transplantation. We established the diabetic rat model by intraperitoneal injection of STZ, which was followed by either islet transplantation or conventional insulin treatment. Compared with insulin treatment, islet transplantation further reduced the elevated blood glucose which was nearly restored to normoglycaemia. In addition, islet transplantation attenuated the increased levels of cTn-I and CK-MB, cleaved-caspase-3 in response to DM, and ameliorated diabetic-induced cardiac hypertrophy and interstitial fibrosis, along with improved extracellular matrix (ECM) deposition. Moreover, diabetic rats that underwent islet transplantation had lower expression of TGF-β1 and lower phosphorylation levels of Smad3. Therefore, islet transplantation exerted protective effect against diabetic-induced myocardial injury and fibrotic remodeling through deactivation of TGF-β1/Smad3 signaling pathway.
资助项目	Natural Science Foundation of China (NSFC) [81170-302]
出版者	E-CENTURY PUBLISHING CORP
ISSN	1943-8141
卷号	10 期号:8 页码:2445-2456.
页数	12
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000443724100018
收录类别	PUBMED ; SCIE
URL	查看原文
PubMed ID	30210683
PMC记录号	PMC6129535
通讯作者地址	[Xiao, Fang-Yi]Wenzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Wenzhou 325000, Zhejiang, Peoples R China. ; [Chen, Bi-Cheng]Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg Lab, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55879
专题	附属第一医院_营养科药学院（分析测试中心）附属第一医院_移植科
通讯作者	Chen, Bi-Cheng; Xiao, Fang-Yi
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg Lab, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Transplantat, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nutr, Wenzhou 325000, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Sch Pharm, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Hong-Wei,Chen, Yi-He,Chen, Yan-Yan,et al. Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β 1/Smad3 pathway[J]. American journal of translational research,2018,10(8):2445-2456..
APA	Wang, Hong-Wei., Chen, Yi-He., Chen, Yan-Yan., Huang, Wei., Zhu, Xian-Dong., ... & Xiao, Fang-Yi. (2018). Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β 1/Smad3 pathway. American journal of translational research, 10(8), 2445-2456..
MLA	Wang, Hong-Wei,et al."Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β 1/Smad3 pathway".American journal of translational research 10.8(2018):2445-2456..