Effect of ademetionine on cytochrome P450 isoforms activity in rats

科研成果详情

题名	Effect of ademetionine on cytochrome P450 isoforms activity in rats
作者	Tong, Shuhua 1; Guo, Jiayi 1; Song, Huanchun 1; Lv, Shiwen 1; Zhu, Yalan 1; Ma, Jianshe2; Zheng, Yuancai3
发表日期	2015-06-15
发表期刊	International journal of clinical and experimental medicine 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CYP450 UPLC-MS/MS ademetionine cocktail rat. rat
其他关键词	ADENOSYL-L-METHIONINE ; ALCOHOLIC LIVER-DISEASE ; IN-VITRO ; OXIDATIVE STRESS ; MASS-SPECTROMETRY ; DRUG-METABOLISM ; COCKTAIL ; INJURY ; ACTIVATION ; EXPRESSION
摘要	Cocktail method was used to evaluate the influence of ademetionine on the activities of CYP450 isoforms CYP1A2, CYP2D6, CYP3A4, CYP2C19, CYP2C9 and CYP2B6, which were reflected by the changes of pharmacokinetic parameters of six specific probe drugs phenacetin, metroprolol, midazolam, omeprazole, tolbutamide and bupropion, respectively. The experimental rats were randomly divided into two group, control group and ademetionine group. The ademetionine group rats were given 50 mg/kg ademetionine by continuous oral administration for 7 days. The mixture of six probes was given to rats through oral administration and the blood samples were obtained at a series of time-points through the caudal vein. The concentrations of probe drugs in rat plasma were measured by UPLC-MS/MS. In the experiment for ademetionine and control group, there was statistical pharmacokinetics difference for phenacetin, metroprolol, midazolam, omeprazole, tolbutamide and bupropion. Continuous oral administration for 7 days could induce the activities of CYP450 isoforms CYP1A2 of rats, while it may inhibit the activities of CYP2D6, CYP3A4, CYP2C19 and CYP2C9.
资助项目	Jinhua Municipal Science and Technology Bureau of social development [2011-3-003]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1940-5901
卷号	8 期号:6 页码:9716-22.
页数	7
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000359295600167
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
Pubmed记录号	26309647
PMC记录号	PMC4538182
Scopus记录号	2-s2.0-84938319653
通讯作者地址	[Zheng, Yuancai]The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55817
专题	基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）附属第一医院
通讯作者	Zheng, Yuancai
作者单位	1.Department of Clinical Pharmacy, Jinhua Central Hospital,Jinhua,321000,China; 2.Function Experiment Teaching Center of Wenzhou Medical University,Wenzhou,325000,China; 3.The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Tong, Shuhua,Guo, Jiayi,Song, Huanchun,et al. Effect of ademetionine on cytochrome P450 isoforms activity in rats[J]. International journal of clinical and experimental medicine,2015,8(6):9716-22..
APA	Tong, Shuhua., Guo, Jiayi., Song, Huanchun., Lv, Shiwen., Zhu, Yalan., ... & Zheng, Yuancai. (2015). Effect of ademetionine on cytochrome P450 isoforms activity in rats. International journal of clinical and experimental medicine, 8(6), 9716-22..
MLA	Tong, Shuhua,et al."Effect of ademetionine on cytochrome P450 isoforms activity in rats".International journal of clinical and experimental medicine 8.6(2015):9716-22..