Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats

科研成果详情

题名	Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats
作者	Cheng, Yi 1,6; Zhang, Jinjing 1; Deng, Liancheng 1,2; Johnson, Noah R 3; Yu, Xichong1; Zhang, Ning 2; Lou, Tianzheng 1; Zhang, Yi 1; Wei, Xiaojie4; Chen, Zaifeng4; He, Songbin 5; Li, Xiaokun1; Xiao, Jian1
发表日期	2015-03-01
发表期刊	International journal of clinical and experimental pathology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ischemic stroke cell transplantation intravenous administration neural stem cells. neural stem cells
其他关键词	MARROW STROMAL CELLS ; CEREBRAL-ISCHEMIA ; INFARCT VOLUME ; TRANSPLANTATION ; MODEL ; INJURY ; REPLACEMENT ; PRECURSORS ; DEFICITS ; THERAPY
摘要	Stem cell transplantation may provide an alternative therapy to promote functional recovery after various neurological disorders including cerebral infarct. Due to the minimal immunogenicity and neuronal differentiation potential of neural stem cells (NSCs), we tested whether intravenous administration of mice-derived C17.2 NSCs could improve neurological function deficit and cerebral infarction volume after ischemic stroke in rats. Additionally, we evaluated the survival, migration, proliferation, and differentiation capacity of transplanted NSCs in the rat brain. Intravenous infusion of NSCs after middle cerebral artery occlusion (MCAO) showed better performance in neurobiological severity scores after MCAO compared to control. However, the volume of cerebral infarction was not different at 7 days after MCAO compared with control. Transplanted NSCs were detected in the ischemic region but not in the contralateral hemisphere. NSCs differentiated into neurons or astrocytes after MCAO. These data suggest that intravenously transplanted NSCs can migrate, proliferate, and differentiate into neurons and astrocytes in the rat brain with focal ischemia and improve functional recovery.
资助项目	National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81000526, 81302775]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [Y2090834]; Zhejiang Provincial Project of Key Scientific Group [2012R10042]; Science Foundation of Ninbo City [2013A610275, 2012A610255]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1936-2625
卷号	8 期号:3 页码:2928-36.
页数	9
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
WOS记录号	WOS:000355312200068
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	26045801
PMC记录号	PMC4440110
SCOPUSEID	2-s2.0-84933034776
通讯作者地址	[Xiao, Jian]Institute of Molecular Pharmacology, School of Pharmaceutics Science, Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Pathology and Forensic Medicine;Histology
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55725
专题	药学院（分析测试中心）_分子药理研究与教学中心研究生工作部（研究生院）其他_附属第六医院（丽水市人民医院）其他_附属舟山医院（舟山医院）其他_附属慈溪医院（慈溪市人民医院）
通讯作者	Xiao, Jian
作者单位	1.Institute of Molecular Pharmacology, School of Pharmaceutics Science, Wenzhou Medical University,Wenzhou,325035,China; 2.Translation Medicine Research Center, Lishui People's Hospital, Wenzhou Medical University,Lishui, Zhejiang,323000,China; 3.Department of Bioengineering, The McGowan Institute for Regenerative Medicine, University of Pittsburgh,Pittsburgh,15219,United States; 4.Department of Neurosurgery, Cixi People's Hospital, Wenzhou Medical University,Ningbo,315300,China; 5.Department of Neurology, Zhoushan Hospital, Wenzhou Medical University,Zhoushan, Zhejiang,316000,China; 6.Department of Pharmacy, Longyou People's Hospital,Quzhou, Zhejiang,324400,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Cheng, Yi,Zhang, Jinjing,Deng, Liancheng,et al. Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats[J]. International journal of clinical and experimental pathology,2015,8(3):2928-36..
APA	Cheng, Yi., Zhang, Jinjing., Deng, Liancheng., Johnson, Noah R., Yu, Xichong., ... & Xiao, Jian. (2015). Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats. International journal of clinical and experimental pathology, 8(3), 2928-36..
MLA	Cheng, Yi,et al."Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats".International journal of clinical and experimental pathology 8.3(2015):2928-36..