The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells

doi:10.22038/ijbms.2016.7816

科研成果详情

题名	The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells
作者	Du, Zhou1; Zhou, Feng 1; Jia, Zengrong 1; Zheng, Beishi1; Han, Shaoliang1; Cheng, Jun1; Zhu, Guanbao1; Huang, Ping 2
发表日期	2016-11-01
发表期刊	Iranian journal of basic medical sciences 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Colorectal cancer Hedgehog/gli-1 Resveratrol Signaling pathways. Signaling pathways
其他关键词	PROLIFERATION ; APOPTOSIS
摘要	Objectives:The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and methods:We chose the appropriate time and concentration of recombinant human Sonic hedgehog (Shh) stimulation by cell viability. The proportion of cell apoptosis was detected by flow cytometry; HCT116 cell migration was measured by scratch test; the expression of Ptch, Smo, and Gli-1 was measured by Western blot analysis. Results:Shh signaling increased HCT116 cell viability and migration, inhibited cell apoptosis, and upregulated the expression of Ptch, Smo, and Gli-1. Resveratrol obviously inhibited HCT116 cell viability and migration, promoted cell apoptosis, and suppressed the protein of Ptch, Smo, and Gli-1. Furthermore, the effects of resveratrol and Shh on human colorectal cancer HCT116 cells were in a dose- and time-dependent manner. Conclusion:The inhibitory effect of resveratrol on HCT116 cells may be mediated by hedgehog/gli-1 signaling pathways.
资助项目	Natural Science Foundation of Zhejiang Province[No.Y15H160192];
出版者	MASHHAD UNIV MED SCIENCES
出版地	MASHHAD
ISSN	2008-3866
EISSN	2008-3874
卷号	19 期号:11 页码:1171-1176.
DOI	10.22038/ijbms.2016.7816
页数	6
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000391089600004
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	27917272
PMC记录号	PMC5126217
SCOPUSEID	2-s2.0-84994479616
通讯作者地址	[Huang, Ping]Office of Development and Planning,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biophysics;Biochemistry;Immunology and Microbiology (all);Drug Discovery;Clinical Biochemistry
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/55613
专题	附属第一医院发展规划处（高教研究所）
通讯作者	Huang, Ping
作者单位	1.Department of Gastrointestinal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 2.Office of Development and Planning,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	发展规划处（校地合作处）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Du, Zhou,Zhou, Feng,Jia, Zengrong,et al. The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells[J]. Iranian journal of basic medical sciences,2016,19(11):1171-1176..
APA	Du, Zhou., Zhou, Feng., Jia, Zengrong., Zheng, Beishi., Han, Shaoliang., ... & Huang, Ping. (2016). The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. Iranian journal of basic medical sciences, 19(11), 1171-1176..
MLA	Du, Zhou,et al."The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells".Iranian journal of basic medical sciences 19.11(2016):1171-1176..