Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells

doi:10.1088/1361-6528/ab5084

科研成果详情

题名	Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells
作者	Qi, Jinxia1,2; Chen, Yonghui 1,2; Xue, Tiantian 1,2; Lin, Yue 3; Huang, Shiyuan1,2; Cao, Shuyan1,2; Wang, Xiaona1,2; Su, Yu1,2; Lin, Zhenkun1,2
发表日期	2020-01-31
发表期刊	NANOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	melittin graphene oxide drug delivery HeLa cell inhibition effect
其他关键词	TARGETED DELIVERY ; DRUG-DELIVERY ; CONTROLLED-RELEASE ; NANOPARTICLES ; DOXORUBICIN ; NANOCARRIER ; THERAPY ; CHOLESTEROL ; MECHANISM ; APOPTOSIS
摘要	Melittin (MEL), the primary active component of bee venom, has recently emerged as a promising cancer chemotherapeutic agent. However, the instability and rapid degradation of MEL is a significant challenge in practical therapeutic applications. In the present study, graphene oxide (GO)-based magnetic nanocomposites (PEG-GO-Fe3O4) were prepared and adopted as the drug delivery vehicles of MEL, and the anticancer effects of PEG-GO-Fe3O4/MEL complexes on human cervical cancer HeLa cells were studied. PEG-GO-Fe3O4 exhibited a series of unique physical and chemical properties resulting in multiple interactions with MEL, and ultimately the release of MEL. In vitro experiments showed that PEG-GO-Fe3O4/MEL not only distinctly enhanced the inhibition effect on HeLa cells, but also induced pore formation in the cell membrane that ultimately led to cell lysis. In this newly developed drug delivery system, PEGylated GO plays the role of a MEL protector while Fe3O4 nanoparticles act as magnetic responders; therefore active MEL can be released over a long period of time (up to 72 h) and maintain its inhibition effect on HeLa cells.
资助项目	Zhejiang Public Welfare Technology Research Project [LGF19H030014, LGF19H170005]; Zhejiang Medical and Health Science & Technology Project [2018PY032]; Zhejiang Province College Students Science and Technology Innovation Project (Xinmiao Talent Program) [2018R413010]
出版者	IOP PUBLISHING LTD
出版地	BRISTOL
ISSN	0957-4484
EISSN	1361-6528
卷号	31 期号:6 页码:65102
DOI	10.1088/1361-6528/ab5084
页数	64
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:000500999600001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20195107871292
EI主题词	Lanthanum compounds
URL	查看原文
PubMed ID	31645027
SCOPUSEID	2-s2.0-85076580529
通讯作者地址	[Lin, Zhenkun]Wenzhou Med Univ, Ctr Sci Res, Affiliated Hosp 2, Wenzhou 325027, Peoples R China. ; [Lin, Zhenkun]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China.
Scopus学科分类	Bioengineering;Chemistry (all);Materials Science (all);Mechanics of Materials;Mechanical Engineering;Electrical and Electronic Engineering
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5509
专题	附属第二医院_科研中心第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Lin, Zhenkun
作者单位	1.Wenzhou Med Univ, Ctr Sci Res, Affiliated Hosp 2, Wenzhou 325027, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China; 3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
第一作者单位	附属第二医院_科研中心; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第二医院_科研中心; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	附属第二医院_科研中心
推荐引用方式 GB/T 7714	Qi, Jinxia,Chen, Yonghui,Xue, Tiantian,et al. Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells[J]. NANOTECHNOLOGY,2020,31(6):65102.
APA	Qi, Jinxia., Chen, Yonghui., Xue, Tiantian., Lin, Yue., Huang, Shiyuan., ... & Lin, Zhenkun. (2020). Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells. NANOTECHNOLOGY, 31(6), 65102.
MLA	Qi, Jinxia,et al."Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells".NANOTECHNOLOGY 31.6(2020):65102.