图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估

doi:10.3760/cma.j.cn511434-20191024-00343

科研成果详情

题名	图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估
其他题名	Evaluation of visual function in central serous chorioretinopathy by pattern reversal visual evoked potential and sweep pattern visual evoked potential
作者	解瑞 1; 崔云 1; 原丽 2; 刘晓玲3
发表日期	2020
发表期刊	中华眼底病杂志影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	中心性浆液性脉络膜视网膜病变诱发电位,视觉
其他关键词	Central serous chorioretinopathy ; Evoked potentials, visual
摘要	目的探讨图形翻转VEP（PRVEP）及扫描图形VEP（SPVEP）在中心性浆液性脉络膜视网膜病变（CSC）视功能评估中的应用价值。方法回顾性临床研究。2016年3月至2018年12月于长治医学院附属和平医院眼科检查确诊的单眼CSC患者38例纳入研究。其中,男性34例,女性4例;平均年龄（40.0±5.2 ）岁。所有患者于急性期（病程≤3个月）和临床治愈期（病程≤6个月）双眼采用德国Roland公司电生理RETIport系统行PRVEP检测,刺激图形采用1.00°和0.25°刺激视角的棋盘格,观察P100波峰幅值和峰时。SPVEP检查设备和方法同PRVEP,空间频率依次为1、2、4、6、8、12、16、22 cpd。比较SPVEP视力与主观视力的差异。患眼与对侧眼PRVEP波峰幅值、峰时及SPVEP振幅、相位比较采用配对t检验;患眼与对侧眼主观视力和SPVEP视力比较采用Wilcoxon配对秩和检验;急性期患眼主观视力与SPVEP视力行Pearson积矩相关分析。结果急性期,患眼P100波峰幅值较对侧眼降低（t=30.26、13.59 ）,峰时延长（t=-19.89、-29.41 ）,差异均有统计学意义（P<0.01 ）;临床治愈期,患眼、对侧眼P100波峰幅值（t=1.49、-0.57）、峰时（t=-1.22、-1.84）比较,差异均无统计学意义（P>0.05 ）。急性期,不同空间频率患眼、对侧眼SPVEP振幅比较,差异均有统计学意义（P<0.01 ）;空间频率1、2、4、6、8、12 cpd,患眼、对侧眼相位比较,差异有统计学意义（P<0.01 ）。临床治愈期,空间频率6、8、12、16 cpd,患眼、对侧眼SPVEP振幅比较,差异有统计学意义（P<0.01 ）;空间频率6、8、12 cpd,患眼、对侧眼SPVEP相位比较,差异有统计学意义（P<0.01 ）。急性期、临床治愈期,患眼SPVEP视力均低于对侧眼,差异有统计学意义（P<0.01）;急性期、临床治愈期,患眼、对侧眼SPVEP视力均低于主观视力,差异有统计学意义（急性期:Z=-5.38、-3.00,P<0.001、0.003;临床治愈期:Z=-5.36、-5.38,P<0.001、<0.001 ）。急性期,患眼主观视力与SPVEP视力呈正相关（r=0.847,P<0.001 ）。结论 PRVEP、SPVEP检查能客观评估CSC视功能改变;对于短期临床治愈CSC,SPVEP可探测细微、潜在的视功能异常。
其他摘要	Objective To investigate the value of pattern reversal visual evoked potential(PRVEP)and sweep pattern visual evoked potential(SPVEP)in evaluating the visual function of patients with central serous chorioretinopathy(CSC).Methods A retrospective clinical trial.A total of 38 monocular CSC patients were enrolled from March 2016 to December2018 in Heping Hospital Affiliated Changzhi Medical College.There were 34 males and 4 females with the mean age of 40.0±5.2 years.All patients undergo PRVEP detection in both the acute phase(disease course ≤ 3 months)and the clinical cure phase(disease course ≤ 6 months)using the German Roland electrophysiological RETIport system.The stimulation pattern adopted a checkerboard with 1.00° and 0.25° stimulation angles.The P100 peak amplitude and peak time were observed.SPVEP inspection equipment and methods were the same as PRVEP,and the spatial frequency was 1,2,4,6,8,12,16,22 cpd.The difference between SPVEP vision and subjective vision were compared.The PRVEP peak amplitude,peak time and SPVEP amplitude and phase of the affected eye and the contralateral eye were compared by paired t test;the subjective vision and SPVEP visual acuity of the affected eye and the contralateral eye were compared by Wilcoxon paired rank test;Pearson product-moment correlation analysis was performed on SPVEP vision.Results In the acute phase,the peak amplitude of P100 in the affected eye was lower than that in the contralateral eye(t=30.26,13.59),and the peak time was prolonged(t=- 19.89,-29.41).The difference was statistically significant(P<0.01);in clinically cured period,the P100 peak amplitude(t=1.49,-0.57)and peak time(t=-1.22,- 1.84)of the affected eye and the contralateral eye showed no significant difference(P>0.05).In the acute phase,the difference in SPVEP amplitude between the affected eye and the contralateral eye with different spatial frequencies was statistically significant(P<0.01);the phase of the affected eye and the contralateral eye were compared about the spatial frequency 1,2,4,6,8,12 cpd,the difference was statistically significant(P<0.01).During the clinical cure period,the spatial frequency of 6,8,12,16 cpd,the SPVEP amplitude of the affected eye and the contralateral eye,the difference was statistically significant(P<0.01);on the spatial frequency of 6,8,12 cpd,the phase of SPVEP was compared between the affected eye and the contralateral eye,the difference was statistically significant(P<0.01).During the acute phase and the clinical cure phase,the SPVEP visual acuity of the affected eye was lower than that of the contralateral eye,and the difference was statistically significant(P<0.01);during the acute phase and clinical cure phase,the SPVEP visual acuity of the affected eye and the contralateral eye were lower than the subjective vision.The difference was statistically significant(acute phase:Z=-5.38,-3.00;P<0.001,0.003;clinical cure phase:Z=-5.36,-5.38;P<0.001<0.001).In the acute phase,the subjective visual acuity of the affected eye was positively correlated with SPVEP visual acuity(r=0.847,P<0.001).Conclusions PRVEP and SPVEP are useful for objectively assessing the visual function of the patients with CSC.Especially,the slight and potential visual impairment in CSC can been detected by SPVEP.
资助项目	山西省卫生健康委员会科研课题（2019137）;山西省高等学校科技创新项目（2017166）;长治医学院博士启动基金（BS17001）
ISSN	1005-1015
卷号	36 期号:9 页码:707-713
DOI	10.3760/cma.j.cn511434-20191024-00343
页数	7
收录类别	CNKI ; 万方 ; SCOPUS ; 维普 ; 北大核心 ; ISTIC ; CSCD ; PKU
学科领域	医药、卫生 ; 眼科学
URL	查看原文
CSCD记录号	CSCD:6812222
SCOPUSEID	2-s2.0-85093533412
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/54431
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_眼底内科
作者单位	1.长治医学院附属和平医院眼科; 2.长治医学院生理学教研室; 3.温州医科大学附属眼视光医院眼底内科
推荐引用方式 GB/T 7714	解瑞,崔云,原丽,等. 图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估[J]. 中华眼底病杂志,2020,36(9):707-713.
APA	解瑞, 崔云, 原丽, & 刘晓玲. (2020). 图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估. 中华眼底病杂志, 36(9), 707-713.
MLA	解瑞,et al."图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估".中华眼底病杂志 36.9(2020):707-713.