Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration

doi:10.3389/fonc.2021.756246

科研成果详情

题名	Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration
作者	Wu, Linfeng 1; Zhou, Yuying 1; Guan, Yaoyao 1; Xiao, Rongyao 1; Cai, Jiaohao 1; Chen, Weike 1; Zheng, Mengmeng 1; Sun, Kaiting 1; Chen, Chao 1; Huang, Guanli2; Zhang, Xiaogang 3,4; Qian, Ziliang 3,4; Shen, Shurong 1
发表日期	2022-01-24
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	thyroid cancer lymphatic metastasis immune infiltration prognosis THCA
其他关键词	AUTOPHAGY ; TIMP1
摘要	ObjectiveSince there are few studies exploring genes associated with lymphatic metastasis of thyroid carcinoma (THCA), this study was conducted to explore genes associated with lymphatic metastasis of THCA and to investigate the relationship with immune infiltration. MethodsDifferentially expressed genes associated with THCA lymphatic metastasis were analyzed based on The Cancer Genome Atlas Program (TCGA) database; a protein-protein interaction(PPI)network was constructed to screen for pivotal genes. Based on the identified hub genes, their expression in THCA with and without lymphatic metastasis were determined. Functional enrichment analysis was performed. The correlation between the identified genes and immune cell infiltration was explored. LASSO logistic regression analysis was performed to determine the risk score of the most relevant gene constructs and multifactor COX regression analysis based on genes in the risk score formula. ResultsA total of 115 genes were differentially expressed in THCA with and without lymphatic metastasis, including 28 upregulated genes and 87 downregulated genes. The PPI network identified seven hub genes (EVA1A, TIMP1, SERPINA1, FAM20A, FN1, TNC, MXRA8); the expression of all seven genes was upregulated in the group with lymphatic metastasis; Immuno-infiltration analysis showed that all seven genes were significantly positively correlated with macrophage M1 and NK cells and negatively correlated with T-cell CD4+ and myeloid dendritic cells. LASSO logistic regression analysis identified the five most relevant genes (EVA1A, SERPINA1, FN1, TNC, MXRA8), and multi-factor COX regression analysis showed EVA1A, SERPINA1 and FN1 as independent prognostic factors. ConclusionSeven genes were associated with lymphatic metastasis of THCA and with tumor immune cell infiltration.
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2234-943X
卷号	11 页码:756246
DOI	10.3389/fonc.2021.756246
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000752038300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35141140
PMC记录号	PMC8818997
SCOPUSEID	2-s2.0-85124237269
通讯作者地址	[Shen, Shurong]Oncology and Hematology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5363
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_甲状腺外科附属第一医院
通讯作者	Shen, Shurong
作者单位	1.Oncology and Hematology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,China; 2.Thyroid Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Hongyuan Biotech,Suzhou Biobay,Suzhou,China; 4.Prophet Genomics Inc,San Jose,United States
推荐引用方式 GB/T 7714	Wu, Linfeng,Zhou, Yuying,Guan, Yaoyao,et al. Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration[J]. FRONTIERS IN ONCOLOGY,2022,11:756246.
APA	Wu, Linfeng., Zhou, Yuying., Guan, Yaoyao., Xiao, Rongyao., Cai, Jiaohao., ... & Shen, Shurong. (2022). Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration. FRONTIERS IN ONCOLOGY, 11, 756246.
MLA	Wu, Linfeng,et al."Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration".FRONTIERS IN ONCOLOGY 11(2022):756246.