Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

doi:10.1155/2016/2546402

科研成果详情

题名	Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9
作者	Yan, Shuangquan 1; Wang, Yiran2; Liu, Panpan 3; Chen, Ali4; Chen, Mayun4; Yao, Dan4; Xu, Xiaomei4; Wang, Liangxing4; Huang, Xiaoying 4
发表日期	2016-12-31
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MUSCLE-CELL MIGRATION ; MATRIX METALLOPROTEINASES ; EXTRACELLULAR-MATRIX ; EXPRESSION ; CANCER ; PROLIFERATION ; INFLAMMATION ; INVASION ; KINASES ; GROWTH
摘要	Baicalin has a protective effect on hypoxia-induced pulmonary hypertension in rats, but the mechanism of this effect remains unclear. Thus, investigating the potential mechanism of this effect was the aim of the present study. Model rats that display hypoxic pulmonary hypertension and cor pulmonale under control conditions were successfully generated. We measured a series of indicators to observe the levels of pulmonary arterial hypertension, pulmonary arteriole remodeling, and right ventricular remodeling. We assessed the activation of p38 mitogen-activated protein kinase (MAPK) in the pulmonary arteriole walls and pulmonary tissue homogenates using immunohistochemistry and western blot analyses, respectively. The matrix metalloproteinase- (MMP-) 9 protein and mRNA levels in the pulmonary arteriole walls were measured using immunohistochemistry and in situ hybridization. Our results demonstrated that baicalin not only reduced p38 MAPK activation in both the pulmonary arteriole walls and tissue homogenates but also downregulated the protein and mRNA expression levels of MMP-9 in the pulmonary arteriole walls. This downregulation was accompanied by the attenuation of pulmonary hypertension, arteriole remodeling, and right ventricular remodeling. These results suggest that baicalin may attenuate pulmonary hypertension and cor pulmonale, which are induced by chronic hypoxia, by downregulating the p38 MAPK/MMP-9 pathway.
资助项目	Health Department of Zhejiang Province of China [2016DTA005, 2012ZDA033]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473406, 81270110]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1741-427X
EISSN	1741-4288
卷号	2016 页码:2546402
DOI	10.1155/2016/2546402
页数	9
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:000383059300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27688788
PMC记录号	PMC5023842
SCOPUSEID	2-s2.0-84987877270
通讯作者地址	[Huang, Xiaoying]Division of Pulmonary Medicine,First Affiliated Hospital of Wenzhou Medical University,Key Laboratory of Heart and Lung,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Complementary and Alternative Medicine
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5344
专题	附属第一医院_设备处
通讯作者	Huang, Xiaoying
作者单位	1.Division of Respiratory Medicine,Taizhou Enze Medical Center Enze Hospital,Taizhou, Zhejiang,318000,China; 2.Division of Equipment,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 3.Division of Intensive Care Unit,Ningbo Medical Center Lihuili Eastern Hospital,Ningbo, Zhejiang,315040,China; 4.Division of Pulmonary Medicine,First Affiliated Hospital of Wenzhou Medical University,Key Laboratory of Heart and Lung,Wenzhou, Zhejiang,325035,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Yan, Shuangquan,Wang, Yiran,Liu, Panpan,et al. Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,2016:2546402.
APA	Yan, Shuangquan., Wang, Yiran., Liu, Panpan., Chen, Ali., Chen, Mayun., ... & Huang, Xiaoying. (2016). Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 2546402.
MLA	Yan, Shuangquan,et al."Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2016(2016):2546402.