Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta 1/Smad2 pathway in a rat model of type 1 diabetes

doi:10.3892/mmr.2021.12015

科研成果详情

题名	Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta 1/Smad2 pathway in a rat model of type 1 diabetes
作者	Zheng, Yuan-Cai1; Feng, Yi-Ling 2; Wang, Yi-Hong2; Kong, Li-Jun 3; Zhou, Ming-Shi 3; Wu, Min-Min3; Liu, Cheng-Yang 4; Weng, Hua-Chun2,5; Wang, Hong-Wei 3
发表日期	2021-05
发表期刊	MOLECULAR MEDICINE REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	diabetes mellitus islet transplantation testicular dysfunction interstitial fibrosis TGF-beta 1/Smad2 signaling
摘要	Islet transplantation (IT) is considered the most effective endocrine replacement therapy for diabetes mellitus (DM). Studies have demonstrated that IT can repair testicular structural injury caused by inflammatory and oxidative stress in a diabetic rat model. However, highly effective exogenous antioxidant and anti-inflammatory drugs can achieve this effect. Testicular interstitial fibrosis caused by long-term hyperglycemia is however difficult to reverse or recover. Thus far, there are no effective drugs that prevent or relieve testicular interstitial fibrosis. Therefore, it is necessary to explore the potential benefit of IT on testicular interstitial fibrosis induced by DM and its underlying molecular mechanisms. In the present study, Wistar rats were used to establish a DM model by intraperitoneal injection of streptozotocin. The diabetic models then underwent IT or received insulin treatment after 12 weeks. IT was more effective than insulin treatment in ameliorating diabetic-induced testicular interstitial fibrosis, Leydig cells apoptosis, testosterone deficiency and poor sperm motility. IT and insulin treatment both significantly inhibited the upregulation of TGF-beta 1 and phosphorylated Smad2 in DM, with IT being more effective than insulin. The present study's findings proved that IT effectively protects diabeticinduced testicular interstitial fibrosis probably by inhibiting the TGF-beta 1/Smad2 signaling pathway, which offers hope in male patients with DM complicating with testicular interstitial fibrosis.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [80216096]; Natural Science Foundation of Zhejiang provinceNatural Science Foundation of Zhejiang Province [84119040G]; Research Incubation Project of The First Affiliated Hospital of Wenzhou Medical University [FHY2019058]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1791-2997
EISSN	1791-3004
卷号	23 期号:5 页码:376
DOI	10.3892/mmr.2021.12015
页数	10
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000631913900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33760134
PMC记录号	PMC7985996
SCOPUSEID	2-s2.0-85103607643
通讯作者地址	[Wang, Hong-Wei]Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,322 Nanbaixiang Street,Wenzhou,325000,China ; [Weng, Hua-Chun]Department of Pediatrics,The First Affiliated Hospital of Wenzhou Medical University,322 Nanbaixiang Street,Wenzhou,325000,China
Scopus学科分类	Biochemistry;Molecular Medicine;Molecular Biology;Genetics;Oncology;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5256
专题	附属第一医院_泌尿外科附属第一医院_儿科第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Wang, Hong-Wei
作者单位	1.Department of Urologym,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Pediatrics,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Surgery,Perelman School of Medicine,The University of Pennsylvania,Philadelphia,19104-5160,United States; 5.The College of Medical Technology,Shanghai University of Medicine and Health Sciences,Shanghai,200000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Yuan-Cai,Feng, Yi-Ling,Wang, Yi-Hong,et al. Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta 1/Smad2 pathway in a rat model of type 1 diabetes[J]. MOLECULAR MEDICINE REPORTS,2021,23(5):376.
APA	Zheng, Yuan-Cai., Feng, Yi-Ling., Wang, Yi-Hong., Kong, Li-Jun., Zhou, Ming-Shi., ... & Wang, Hong-Wei. (2021). Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta 1/Smad2 pathway in a rat model of type 1 diabetes. MOLECULAR MEDICINE REPORTS, 23(5), 376.
MLA	Zheng, Yuan-Cai,et al."Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta 1/Smad2 pathway in a rat model of type 1 diabetes".MOLECULAR MEDICINE REPORTS 23.5(2021):376.