题名 | Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats |
作者 | |
发表日期 | 2011-07 |
发表期刊 | NEURAL REGENERATION RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Zhutan Tongluo Tang intracerebral hemorrhage tissue plasminogen activator plasminogen activator inhibitor-1 D-Dimer hippocampus apoptosis neural regeneration |
其他关键词 | TISSUE-PLASMINOGEN ACTIVATOR ; EDEMA FORMATION ; APOPTOSIS ; STROKE ; INFLAMMATION ; INJURY ; DEATH ; MODEL |
摘要 | The neuroprotective effect of Zhutan Tongluo Tang is associated with the activities of the fibrinolytic system. Thus the present study was designed to investigate therapeutic effects of Zhutan Tongluo Tang on intracerebral hemorrhage in rats, induced by injecting collagenase into one side of the caudate nucleus. Fibrinolytic indices including tissue plasminogen activator, plasminogen activator inhibitor-1 and D-Dimer were determined. The results obtained demonstrated that Zhutan Tongluo Tang treatment could alleviate the neural and behavioral impairments of intracerebral hemorrhaging rats. Increased frequencies of placing their forelimb correctly and decreased frequencies of turning left were observed. Enzyme linked immunosorbent assay showed that Zhutan Tongluo Tang could significantly elevate the concentration of plasma tissue plasminogen activator and D-Dimer, while depress plasminogen activator inhibitor-1. Immunohistochemistry demonstrated increased levels of catalase and glutathione in whole brain rat tissue following intracerebral hemorrhage. In addition, elevated expression of Bcl-2 in various hippocampal regions was seen. These findings describe the ability of Zhutan Tongluo Tang to activate the fibrinolytic system, and suggests that antioxidant and apoptosis inhibitory mechanisms may be playing a crucial role in protecting against collagenase-induced intracerebral hemorrhage. |
资助项目 | Wenzhou Science and Technology Bureau [Y20060700] |
出版者 | WOLTERS KLUWER MEDKNOW PUBLICATIONS |
出版地 | MUMBAI |
ISSN | 1673-5374 |
EISSN | 1876-7958 |
卷号 | 6期号:21页码:1640-1645 |
DOI | 10.3969/j.issn.1673-5374.2011.21.007 |
页数 | 6 |
WOS类目 | Cell Biology ; Neurosciences |
WOS研究方向 | Cell Biology ; Neurosciences & Neurology |
WOS记录号 | WOS:000294537500007 |
收录类别 | SCIE ; SCOPUS ; CSCD |
学科领域 | 医药、卫生 ; 外科学 |
URL | 查看原文 |
CSCD记录号 | CSCD:4310651 |
SCOPUSEID | 2-s2.0-80051958719 |
通讯作者地址 | [Liu, Shijue]Wenzhou Med Coll, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/5246 |
专题 | 第二临床医学院,附属第二医院、育英儿童医院 基础医学院(机能实验教学中心)_机能学系_生理学 |
通讯作者 | Liu, Shijue |
作者单位 | 1.Wenzhou Med Coll, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Municipal Hosp Tradit Chinese Med, Dept Rehabil, Wenzhou 325005, Zhejiang, Peoples R China; 3.Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Zhejiang, Peoples R China; 4.Ningbo TianYi Vocat & Tech Coll, Dept Pharmacol, Ningbo 315100, Zhejiang, Peoples R China; 5.Cent Hosp Xinyang, Dept Urol, Xinyang 464000, Henan Province, Peoples R China |
通讯作者单位 | 第二临床医学院,附属第二医院、育英儿童医院 |
推荐引用方式 GB/T 7714 | Jin, Yongxi,Li, Xu,Li, Gaowen,et al. Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats[J]. NEURAL REGENERATION RESEARCH,2011,6(21):1640-1645. |
APA | Jin, Yongxi., Li, Xu., Li, Gaowen., Guo, Lei., Li, Fang., ... & Liu, Shijue. (2011). Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats. NEURAL REGENERATION RESEARCH, 6(21), 1640-1645. |
MLA | Jin, Yongxi,et al."Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats".NEURAL REGENERATION RESEARCH 6.21(2011):1640-1645. |
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