科研成果详情

题名Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats
作者
发表日期2011-07
发表期刊NEURAL REGENERATION RESEARCH   影响因子和分区
语种英语
原始文献类型Article
关键词Zhutan Tongluo Tang intracerebral hemorrhage tissue plasminogen activator plasminogen activator inhibitor-1 D-Dimer hippocampus apoptosis neural regeneration
其他关键词TISSUE-PLASMINOGEN ACTIVATOR ; EDEMA FORMATION ; APOPTOSIS ; STROKE ; INFLAMMATION ; INJURY ; DEATH ; MODEL
摘要The neuroprotective effect of Zhutan Tongluo Tang is associated with the activities of the fibrinolytic system. Thus the present study was designed to investigate therapeutic effects of Zhutan Tongluo Tang on intracerebral hemorrhage in rats, induced by injecting collagenase into one side of the caudate nucleus. Fibrinolytic indices including tissue plasminogen activator, plasminogen activator inhibitor-1 and D-Dimer were determined. The results obtained demonstrated that Zhutan Tongluo Tang treatment could alleviate the neural and behavioral impairments of intracerebral hemorrhaging rats. Increased frequencies of placing their forelimb correctly and decreased frequencies of turning left were observed. Enzyme linked immunosorbent assay showed that Zhutan Tongluo Tang could significantly elevate the concentration of plasma tissue plasminogen activator and D-Dimer, while depress plasminogen activator inhibitor-1. Immunohistochemistry demonstrated increased levels of catalase and glutathione in whole brain rat tissue following intracerebral hemorrhage. In addition, elevated expression of Bcl-2 in various hippocampal regions was seen. These findings describe the ability of Zhutan Tongluo Tang to activate the fibrinolytic system, and suggests that antioxidant and apoptosis inhibitory mechanisms may be playing a crucial role in protecting against collagenase-induced intracerebral hemorrhage.
资助项目Wenzhou Science and Technology Bureau [Y20060700]
出版者WOLTERS KLUWER MEDKNOW PUBLICATIONS
出版地MUMBAI
ISSN1673-5374
EISSN1876-7958
卷号6期号:21页码:1640-1645
DOI10.3969/j.issn.1673-5374.2011.21.007
页数6
WOS类目Cell Biology ; Neurosciences
WOS研究方向Cell Biology ; Neurosciences & Neurology
WOS记录号WOS:000294537500007
收录类别SCIE ; SCOPUS ; CSCD
学科领域医药、卫生 ; 外科学
URL查看原文
CSCD记录号CSCD:4310651
SCOPUSEID2-s2.0-80051958719
通讯作者地址[Liu, Shijue]Wenzhou Med Coll, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China.
引用统计
被引频次[WOS]:0   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/5246
专题第二临床医学院,附属第二医院、育英儿童医院
基础医学院(机能实验教学中心)_机能学系_生理学
通讯作者Liu, Shijue
作者单位
1.Wenzhou Med Coll, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China;
2.Wenzhou Municipal Hosp Tradit Chinese Med, Dept Rehabil, Wenzhou 325005, Zhejiang, Peoples R China;
3.Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Zhejiang, Peoples R China;
4.Ningbo TianYi Vocat & Tech Coll, Dept Pharmacol, Ningbo 315100, Zhejiang, Peoples R China;
5.Cent Hosp Xinyang, Dept Urol, Xinyang 464000, Henan Province, Peoples R China
通讯作者单位第二临床医学院,附属第二医院、育英儿童医院
推荐引用方式
GB/T 7714
Jin, Yongxi,Li, Xu,Li, Gaowen,et al. Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats[J]. NEURAL REGENERATION RESEARCH,2011,6(21):1640-1645.
APA Jin, Yongxi., Li, Xu., Li, Gaowen., Guo, Lei., Li, Fang., ... & Liu, Shijue. (2011). Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats. NEURAL REGENERATION RESEARCH, 6(21), 1640-1645.
MLA Jin, Yongxi,et al."Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats".NEURAL REGENERATION RESEARCH 6.21(2011):1640-1645.

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