NEUROMUSCULAR BLOCKING AND RESPIRATORY DEPRESSING ACTIONS OF SODIUM AMMONIUM DIMETHYL-2-(PROPANO-1,3-DITHIOSULFATE) MONOHYDRATE

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题名	NEUROMUSCULAR BLOCKING AND RESPIRATORY DEPRESSING ACTIONS OF SODIUM AMMONIUM DIMETHYL-2-(PROPANO-1,3-DITHIOSULFATE) MONOHYDRATE
作者	CAO, BJ ; CHEN, ZK ; CHI, ZQ
发表日期	1990-05
发表期刊	ACTA PHARMACOLOGICA SINICA 影响因子和分区
语种	中文
原始文献类型	Article
摘要	The neuromuscular blocking and respiratory depressing actions of the new insecticide sodium ammonium dimethyl-2-(propano-1,3-dithiosulfate) monohydrate (SCD) were investigated. In peroneal-tibialis anterior nerve-muscle preparations of urethane anesthetized rabbit, SCD 6.5 mg/kg iv completely depressed the indirectly elicited twitch tension but not the directly elicited one. This compound also caused initial potentiation of the indirectly elicited twitch tension. In the partially paralyzed preparations, potentiation of contractions occurred following a brief period of indirectly tetanic stimulation. Nereistoxin but not SCD blocked the indirectly elicited twitch tension of isolated rat diaphragm. The neuromuscular blockade induced by SCD and nereistoxin was antagonized by neostigmine and 4-aminopyridine. SCD and nereistoxin had little or no effect on arterial blood pressure and phrenic nerve discharge of rabbits. The results indicated that SCD-poisoned rabbits died of respiratory paralysis following the neuromuscular blockade.
出版者	ACTA PHARMACOLOGICA SINICA
出版地	SHANGHAI
ISSN	0253-9756
EISSN	1745-7254
卷号	11 期号:3 页码:207-210
页数	4
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS记录号	WOS:A1990DC72700005
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	1965089
SCOPUSEID	2-s2.0-0025088152
TOP期刊	TOP期刊
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5192
专题	药学院（分析测试中心）_临床药学与药理系药学院（分析测试中心）_药学系药学院（分析测试中心）_临床药学与药理系_药理学
作者单位	1.WENZHOU MED COLL, DEPT PHARMACOL, WENZHOU 325003, PEOPLES R CHINA; 2.ACAD SINICA, SHANGHAI INST MAT MED CHINESE, SHANGHAI 200031, PEOPLES R CHINA
推荐引用方式 GB/T 7714	CAO, BJ,CHEN, ZK,CHI, ZQ. NEUROMUSCULAR BLOCKING AND RESPIRATORY DEPRESSING ACTIONS OF SODIUM AMMONIUM DIMETHYL-2-(PROPANO-1,3-DITHIOSULFATE) MONOHYDRATE[J]. ACTA PHARMACOLOGICA SINICA,1990,11(3):207-210.
APA	CAO, BJ, CHEN, ZK, & CHI, ZQ. (1990). NEUROMUSCULAR BLOCKING AND RESPIRATORY DEPRESSING ACTIONS OF SODIUM AMMONIUM DIMETHYL-2-(PROPANO-1,3-DITHIOSULFATE) MONOHYDRATE. ACTA PHARMACOLOGICA SINICA, 11(3), 207-210.
MLA	CAO, BJ,et al."NEUROMUSCULAR BLOCKING AND RESPIRATORY DEPRESSING ACTIONS OF SODIUM AMMONIUM DIMETHYL-2-(PROPANO-1,3-DITHIOSULFATE) MONOHYDRATE".ACTA PHARMACOLOGICA SINICA 11.3(1990):207-210.