Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD

doi:10.3389/fnhum.2018.00279

科研成果详情

题名	Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD
作者	Qian, Andan1; Tao, Jiejie1; Wang, Xin 2; Liu, Huiru1; Ji, Lingxiao 1; Yang, Chuang3; Ye, Qiong1; Chen, Chengchun4; Li, Jiance1; Cheng, Jingliang 5; Wang, Meihao1; Zhao, Ke6
发表日期	2018-07-12
发表期刊	FRONTIERS IN HUMAN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	attention-deficit hyperactivity disorder functional magnetic resonance imaging DRD4 2-repeat allele group independent component analysis
其他关键词	ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DEFICIT HYPERACTIVITY DISORDER ; RESTING-STATE NETWORKS ; DOPAMINE-D4 RECEPTOR GENE ; DEVELOPMENTAL COORDINATION DISORDER ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; EXECUTIVE FUNCTIONS ; DECISION-MAKING ; PREMOTOR CORTEX
摘要	Objective: Genetic variation, especially polymorphism of the dopamine D4 receptor gene (DRD4), has been linked to deficits in self-regulation and executive functions and to attention deficit hyperactivity disorder (ADHD), and is related to the structural and functional integrity of the default mode network (DMN), the executive control network (ECN) and the sensorimotor network (SMN). The aim of this study was to explore the effects of the 2-repeat allele of the DRD4 gene on brain network connectivity and behaviors in children with ADHD. Methods: Using independent component analysis (ICA) and dimension analyses, we examined resting-state functional magnetic resonance imaging (fMRI) data obtained from 52 Asian medicine-naive children with ADHD (33 2-repeat absent and 19 2-repeat present). Results: We found that individuals with 2-repeat absent demonstrated increased within-network connectivity in the right precuneus of the DMN, the right middle frontal gyrus (MFG) of the SMN compared with individuals with 2-repeat present. Within the ECN, 2-repeat absent showed decreased within-network connectivity in the left inferior frontal gyrus (IFG) and the left anterior cingulate cortex. A deeper study found that connectivity strength of the left IFG was directly proportional to the Stroop reaction time in 2-repeat absent group, and as well as the right MFG in 2-repeat present group. Conclusion: Polymorphisms of the DRD4 gene, specifically 2-repeat allele, had effects on the ECN, the SMN and the DMN, especially in the prefrontal cortex (PFC) circles. ADHD children with DRD4 2-repeat allele have aberrant resting-state within-network connectivity patterns in the left IFG and the right MFG related to dysfunction in inattention symptom. This study provided novel insights into the neural mechanisms underlying the effects of DRD4 2-repeat allele on ADHD.
资助项目	Natural Science Foundation of Zhejiang Province, ChinaNatural Science Foundation of Zhejiang Province [LY14H180006, LQ18H090009]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20160142]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-5161
卷号	12 页码:279
DOI	10.3389/fnhum.2018.00279
页数	12
WOS类目	Neurosciences ; Psychology
WOS研究方向	Neurosciences & Neurology ; Psychology
WOS记录号	WOS:000438412800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30050420
PMC记录号	PMC6052087
SCOPUSEID	2-s2.0-85055081799
通讯作者地址	[Wang, Meihao]Department of Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neuropsychology and Physiological Psychology;Neurology;Psychiatry and Mental Health;Biological Psychiatry;Behavioral Neuroscience
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5041
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科附属第一医院_精神卫生科精神医学学院基础医学院（机能实验教学中心）_形态学系_人体解剖学
通讯作者	Wang, Meihao
作者单位	1.Department of Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Radiology,Yancheng First Peoples’ Hospital,Yancheng,China; 3.Department of Mental Health,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Anatomy,Wenzhou Medical University,Wenzhou,China; 5.Department of Radiology,First Affiliated Hospital of Zhengzhou University,Zhengzhou,China; 6.School of Mental Health,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Qian, Andan,Tao, Jiejie,Wang, Xin,et al. Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,12:279.
APA	Qian, Andan., Tao, Jiejie., Wang, Xin., Liu, Huiru., Ji, Lingxiao., ... & Zhao, Ke. (2018). Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD. FRONTIERS IN HUMAN NEUROSCIENCE, 12, 279.
MLA	Qian, Andan,et al."Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD".FRONTIERS IN HUMAN NEUROSCIENCE 12(2018):279.