题名 | Uterotubal junction prevents chlamydial ascension via innate immunity |
作者 | |
发表日期 | 2017-08-10 |
发表期刊 | PLOS ONE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | UPPER GENITAL-TRACT ; TUBAL FACTOR INFERTILITY ; CD8(+) T-CELLS ; MURIDARUM INFECTION ; ANTIMICROBIAL PEPTIDES ; PROTECTIVE IMMUNITY ; EPITHELIAL-CELLS ; MICE ; PATHOLOGY ; OVIDUCT |
摘要 | Ascension to the oviduct is necessary for Chlamydia to induce tubal infertility. Using the Chlamydia muridarum induction of hydrosalpinx mouse model, we have demonstrated a significant role of the uterotubal junction in preventing chlamydial ascending infection. First, delivery of C. muridarum to either side of the uterotubal junction resulted in significant reduction in live organisms from the tissues on the opposite sides. However, the recovery yields remained similar among different sections of the uterine horn. These observations suggest that the uterotubal junction may function as a barrier between the uterine horn and oviduct. Second, deficiency in innate immunity signaling pathways mediated by either MyD88 or STING significantly compromised the uterotubal junction barrier function, permitting C. muridarum to spread freely between uterine horn and oviduct. Finally, transcervical inoculation of C. muridarum led to significantly higher incidence of bilateral hydrosalpinges in the STING-deficient mice while the same inoculation mainly induced unilateral hydrosalpinx in the wild type mice, suggesting that the STING pathway-dependent uterotubal junction plays a significant role in preventing tubal pathology. Thus, we have demonstrated for the first time that the uterotubal junction is a functional barrier for preventing tubal infection by a sexually transmitted agent, providing the first in vivo evidence for detecting chlamydial infection by the STING pathway. |
资助项目 | US National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Wenzhou Medical University in China |
出版者 | PUBLIC LIBRARY SCIENCE |
出版地 | SAN FRANCISCO |
ISSN | 1932-6203 |
卷号 | 12期号:8页码:e0183189. |
DOI | 10.1371/journal.pone.0183189 |
页数 | 17 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
WOS记录号 | WOS:000407396200154 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 28797102 |
PMC记录号 | PMC5552320 |
SCOPUSEID | 2-s2.0-85027351836 |
通讯作者地址 | [Zhong, Guangming]Department of Microbiology and Immunology,University of Texas Health Science Center at San Antonio,TX,United States |
Scopus学科分类 | Multidisciplinary |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/4994 |
专题 | 附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院_妇产科学 |
通讯作者 | Zhong, Guangming |
作者单位 | 1.Department of Obstetrics and Gynecology,Wenzhou Medical University,Wenzhou,China; 2.Department of Microbiology and Immunology,University of Texas Health Science Center at San Antonio,TX,United States |
第一作者单位 | 温州医科大学 |
第一作者的第一单位 | 温州医科大学 |
推荐引用方式 GB/T 7714 | Zhang, Yuyang,Shao, Lili,Li, Xiaodong,et al. Uterotubal junction prevents chlamydial ascension via innate immunity[J]. PLOS ONE,2017,12(8):e0183189.. |
APA | Zhang, Yuyang, Shao, Lili, Li, Xiaodong, & Zhong, Guangming. (2017). Uterotubal junction prevents chlamydial ascension via innate immunity. PLOS ONE, 12(8), e0183189.. |
MLA | Zhang, Yuyang,et al."Uterotubal junction prevents chlamydial ascension via innate immunity".PLOS ONE 12.8(2017):e0183189.. |
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