科研成果详情

题名Uterotubal junction prevents chlamydial ascension via innate immunity
作者
发表日期2017-08-10
发表期刊PLOS ONE   影响因子和分区
语种英语
原始文献类型Article
其他关键词UPPER GENITAL-TRACT ; TUBAL FACTOR INFERTILITY ; CD8(+) T-CELLS ; MURIDARUM INFECTION ; ANTIMICROBIAL PEPTIDES ; PROTECTIVE IMMUNITY ; EPITHELIAL-CELLS ; MICE ; PATHOLOGY ; OVIDUCT
摘要Ascension to the oviduct is necessary for Chlamydia to induce tubal infertility. Using the Chlamydia muridarum induction of hydrosalpinx mouse model, we have demonstrated a significant role of the uterotubal junction in preventing chlamydial ascending infection. First, delivery of C. muridarum to either side of the uterotubal junction resulted in significant reduction in live organisms from the tissues on the opposite sides. However, the recovery yields remained similar among different sections of the uterine horn. These observations suggest that the uterotubal junction may function as a barrier between the uterine horn and oviduct. Second, deficiency in innate immunity signaling pathways mediated by either MyD88 or STING significantly compromised the uterotubal junction barrier function, permitting C. muridarum to spread freely between uterine horn and oviduct. Finally, transcervical inoculation of C. muridarum led to significantly higher incidence of bilateral hydrosalpinges in the STING-deficient mice while the same inoculation mainly induced unilateral hydrosalpinx in the wild type mice, suggesting that the STING pathway-dependent uterotubal junction plays a significant role in preventing tubal pathology. Thus, we have demonstrated for the first time that the uterotubal junction is a functional barrier for preventing tubal infection by a sexually transmitted agent, providing the first in vivo evidence for detecting chlamydial infection by the STING pathway.
资助项目US National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Wenzhou Medical University in China
出版者PUBLIC LIBRARY SCIENCE
出版地SAN FRANCISCO
ISSN1932-6203
卷号12期号:8页码:e0183189.
DOI10.1371/journal.pone.0183189
页数17
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
WOS记录号WOS:000407396200154
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID28797102
PMC记录号PMC5552320
SCOPUSEID2-s2.0-85027351836
通讯作者地址[Zhong, Guangming]Department of Microbiology and Immunology,University of Texas Health Science Center at San Antonio,TX,United States
Scopus学科分类Multidisciplinary
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/4994
专题附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院_妇产科学
通讯作者Zhong, Guangming
作者单位
1.Department of Obstetrics and Gynecology,Wenzhou Medical University,Wenzhou,China;
2.Department of Microbiology and Immunology,University of Texas Health Science Center at San Antonio,TX,United States
第一作者单位温州医科大学
第一作者的第一单位温州医科大学
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GB/T 7714
Zhang, Yuyang,Shao, Lili,Li, Xiaodong,et al. Uterotubal junction prevents chlamydial ascension via innate immunity[J]. PLOS ONE,2017,12(8):e0183189..
APA Zhang, Yuyang, Shao, Lili, Li, Xiaodong, & Zhong, Guangming. (2017). Uterotubal junction prevents chlamydial ascension via innate immunity. PLOS ONE, 12(8), e0183189..
MLA Zhang, Yuyang,et al."Uterotubal junction prevents chlamydial ascension via innate immunity".PLOS ONE 12.8(2017):e0183189..

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