IL-10、IFN-γ对儿童噬血细胞综合征的检测意义

doi:10.3969/j.issn.2095-9400.2015.03.016

科研成果详情

题名	IL-10、IFN-γ对儿童噬血细胞综合征的检测意义
其他题名	IL-10, IFN-γ for the study of the signiifcance of detecting for children with hemophagocytic syndrome
作者	徐智胜; 郑双利; 李原; 曾炜炜; 陈敏; 钱江潮
发表日期	2015-03-25
发表期刊	温州医科大学学报影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	儿童噬血细胞淋巴组织细胞增生症噬血细胞综合征细胞因子诊断价值
其他关键词	children ; hemophagocytic lymphohistiocytosis ; hemophagocytic syndrome ; cytokines ; value of diagnosis
摘要	目的:评价血清IL-6、IL-10、IL-18、IFN-γ对儿童噬血细胞综合征(HPS)的早期诊断及预后的价值。方法:采用前瞻性研究方法,对20例诊断为HPS患儿分成治疗前和治疗后,以20例正常体检儿童作为阴性正常对照组,再选取缓解期急性淋巴细胞白血病(ALL)18例和脓毒症患儿22例血清作为阳性对照组。通过流式细胞仪流式微球术对血清IL-6、IL-10、IL-18、IFN-γ水平进行测定。比较患儿治疗前后和不同分组之间血清4种细胞因子水平。结果:4种细胞因子水平随患儿HPS治疗前后明显变化,治疗前4种细胞因子水平明显高于治疗后和正常对照组,差异有统计学意义(P<0.05);HPS患儿IL-10、IFN-γ水平较正常对照组、ALL患儿组及脓毒症患儿组显著升高,差异有统计学意义(P<0.05)。结论:HPS患儿IL-10和IFN-γ水平相比ALL和脓毒症患儿显著升高,可以作为儿童HPS早期诊断和预测预后的临床指标。
其他摘要	Objective: To evaluate serum IL-6, IL-10, IL-18, IFN-γ for the value of early diagnosis and prognosis of children with hemophagocytic syndrome.Methods: By using the method of prospective study of 20 children with a diagnosis of HPS into diagnosis before treatment and after treatment, while at the same time, with 20 cases normal physical examination children as normal control group, then choose the remission of acute lym-phoblastic leukemia (ALL), 18 cases and sepsis were 22 cases of serum were chosen as positive control group. IL-6, IL-10, IL-18, IFN-γ levels were determined with lfow cytometry instrument lfow ball technique. Four kinds of cytokines serum levels before and after treatment between different groups were compared.Results:Four kinds of cytokines levels obriously varied with HPS before and after treatment in children, 4 kinds of cytokines during the diagnosis level was signiifcantly higher than that of the normal control group after treatment (P<0.05), children with HPS of IL-10 and level of IFN-γ obviously elevated compared with normal controls, children with acute leukemia and the cases of sepsis was signiifcant difference (P<0.05).Conclusion: Cytokines IL-10 and IFN-γ levels in children with HPS before treatment is signiifcantly elevated compared with the control group, then markedly reduced for treatment, so it can be used as a children’s early diagnosis and prognosis prediction of HPS clinical indicator.
资助项目	温州市科技局科研基金资助项目（Y20100055）
ISSN	2095-9400
卷号	45 期号:03 页码:218-221
DOI	10.3969/j.issn.2095-9400.2015.03.016
页数	4
收录类别	CNKI ; 万方 ; 维普 ; ISTIC
URL	查看原文
社科自定义期刊分类	G类
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/49834
专题	附属第二医院_儿童血液科
作者单位	温州医科大学附属第二医院儿童血液科
第一作者单位	附属第二医院_儿童血液科
第一作者的第一单位	附属第二医院_儿童血液科
推荐引用方式 GB/T 7714	徐智胜,郑双利,李原,等. IL-10、IFN-γ对儿童噬血细胞综合征的检测意义[J]. 温州医科大学学报,2015,45(03):218-221.
APA	徐智胜, 郑双利, 李原, 曾炜炜, 陈敏, & 钱江潮. (2015). IL-10、IFN-γ对儿童噬血细胞综合征的检测意义. 温州医科大学学报, 45(03), 218-221.
MLA	徐智胜,et al."IL-10、IFN-γ对儿童噬血细胞综合征的检测意义".温州医科大学学报 45.03(2015):218-221.