急性颅脑损伤患儿血清HMGB1的变化及其临床意义

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题名	急性颅脑损伤患儿血清HMGB1的变化及其临床意义
其他题名	The changes and clinical significance of serum high mobility group box-1 protein level of children's patients with acute traumatic brain injury
作者	王林霞; 汤鲁明; 王敏; 严纯雪; 潘国权
发表日期	2015-08-08
发表期刊	中国现代医生影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	急性颅脑损伤高迁移率族蛋白B1 儿童患者脓毒症急性肺损伤
其他关键词	Acute traumatic brain injury ; High mobility group box-1 protein ; Children patients ; Sepsis ; Acute lung injury
摘要	目的探讨TBI患儿早期外周血HMGB1表达变化及其临床意义。方法将87例急性TBI患儿根据格拉斯哥评分分成三组:严重组(≤8分)、中度组(9~12分)、轻度组(13~15分),分别在伤后3 h、6 h、12 h、24 h、48 h采集静脉血,采用酶联免疫吸附试验(ELISA)检测血清HMGB1含量;同时根据严重组患儿28 d内是否死亡、是否发生脓毒症或急性肺损伤分组,比较组间HMGB1的表达。结果重度组在各时间点HMGB1水平均显著高于轻、中度组(P<0.01);中度损伤组较轻度损伤组在6 h、12 h、24 h、48 h明显升高(P<0.01);死亡组患者血清HMGB1水平较存活组显著升高(P<0.01);发生脓毒症及急性肺损伤病例血清HMGB1显著均高于未发生脓毒症及急性肺损伤病例(P<0.01)。结论颅脑损伤患儿早期血清HMGB1即升高,且可能作为一种"预警信号"预测损伤严重度及预后、并发症的发生。
其他摘要	Objective To investigate the serum high mobility group box-1 protein level of children's patients with a-cute traumatic brain injury and it's expression changes and clinical significance. Methods A total of 87 children's patients with acute traumatic brain injury were randomly divided into three groups: severe group (≤8 scores), moderate group(9 to 12 scores) and minor group(13 to 15 scores) according to the patients' Glasgow Coma Scale on admission. Their venous blood were drawn at 3 h, 6 h, 12 h, 24 h, 48 h after injury and the serum HMGB1 were determined by en zyme linked immunosorbent assay(ELISA). The serum HMGB1 concentration were compared between different groups, survivors and non-survivors in 28 days, patients who developed acute lung injury(ALI) or sepsis and who did not deve-lope ALI or sepsis in severe injury group. Results Compared with the minor and moderate group, the serum HMGB1 level in severe group were significantly elevated at each time points(P<0.01). At 6 h, 12 h, 24 h, 48 h time points, the serum HMGB1 level in the moderate group increased significantly compared with the minor group (P<0.01). The serum HMGB1 levels at 24 h after injury were higher in non-survivors compared with survivors (P<0.01). The serum HMGB1 levels in those patients who developed acute lung injury (ALI) or sepsis were higher than who did not develope ALI or sepsis (P<0.01). Conclusion The serum HMGB1 concentration is increased early and may be a ‘alarm signal'prog-nosticating prognosis and complication after acute traumatic brain injury in children.
资助项目	浙江省温州市科技计划项目（Y20120108）;浙江省医药卫生科技计划项目（2013RCA039）
ISSN	1673-9701
卷号	53 期号:22 页码:5-8
页数	4
收录类别	CNKI ; 万方 ; 维普
URL	查看原文
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/48868
专题	附属第二医院_儿童ICU
作者单位	温州医科大学附属第二医院儿童ICU
第一作者单位	附属第二医院_儿童ICU
第一作者的第一单位	附属第二医院_儿童ICU
推荐引用方式 GB/T 7714	王林霞,汤鲁明,王敏,等. 急性颅脑损伤患儿血清HMGB1的变化及其临床意义[J]. 中国现代医生,2015,53(22):5-8.
APA	王林霞, 汤鲁明, 王敏, 严纯雪, & 潘国权. (2015). 急性颅脑损伤患儿血清HMGB1的变化及其临床意义. 中国现代医生, 53(22), 5-8.
MLA	王林霞,et al."急性颅脑损伤患儿血清HMGB1的变化及其临床意义".中国现代医生 53.22(2015):5-8.

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