Combination Treatment of Citral Potentiates the Efficacy of Hyperthermic Intraperitoneal Chemoperfusion with Pirarubicin for Colorectal Cancer

doi:10.1021/acs.molpharmaceut.7b00652

科研成果详情

题名	Combination Treatment of Citral Potentiates the Efficacy of Hyperthermic Intraperitoneal Chemoperfusion with Pirarubicin for Colorectal Cancer
作者	Fang, Zhiyuan 1,2; Wang, Yu1; Li, Hao 1; Yu, Shuaishuai3; Liu, Ziying 1; Fan, Zhichao 1; Chen, Xiaomin 1; Wu, Yuying1; Pan, Xuebo1; Li, Xiaokun1; Wang, Cong1
发表日期	2017-10
发表期刊	MOLECULAR PHARMACEUTICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	hyperthermic intraperitoneal chemoperfusion citral pirarubicin apoptosis colorectal carcinoma
其他关键词	CYTOREDUCTIVE SURGERY ; ESSENTIAL OILS ; PERITONEAL CARCINOMATOSIS ; PENETRATION ENHANCERS ; CHEMOTHERAPY ; DELIVERY ; HIPEC ; CONSTITUENTS ; FORMULATION ; ADRIAMYCIN
摘要	Citral is a widely used penetration enhancer that has been used to assist the delivery of drugs through the skin. In this study we aimed to investigate the effectiveness of combination treatments of citral with hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal cancer and to unravel the underlying mechanism by which citral increased the efficacy of HIPEC. In vitro experiments indicated that citral increased cytoplasmic absorption of pirarubicin and potentiated the effects of pirarubicin on colorectal cancer cells to induce apoptosis. Intracellular reactive oxygen species (ROS) activity was elevated after single or combo treatments with pirarubicin, leading to compromised NF-kappa B signaling. Therefore, the results suggested that the effects of citral were mediated by increasing cell permeability and ROS productions. Furthermore, the colorectal xenograft model was used to evaluate the efficacy of the combo treatment at the histological and molecular levels, which showed that the cotreatment with citral for colorectal cancer increased the efficacy of HIPEC with pirarubicin with respect to both ascite control and tumor load. The results indicated that citral was an effective additive for HIPEC with pirarubicin for colorectal cancer, which warrant further effort to explore the translational application of this new treatment regimen.
资助项目	Natural Science Foundation of Zhejiang Province of ChinaNatural Science Foundation of Zhejiang Province [LY16H140004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371470, 81270761, 81602246, 81602608]; Natural Science Foundation of Ningbo City [2015A610198]; Talent project foundation of Wenzhou Medical University [QTJ14030]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	1543-8384
EISSN	1543-8392
卷号	14 期号:10 页码:3588-3597
DOI	10.1021/acs.molpharmaceut.7b00652
页数	10
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000412379100034
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28841022
SCOPUSEID	2-s2.0-85030633813
通讯作者地址	[Pan, Xuebo]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,325030,China
Scopus学科分类	Molecular Medicine;Pharmaceutical Science;Drug Discovery
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4867
专题	药学院（分析测试中心）检验医学院（生命科学学院、生物学实验教学中心）基础医学院（机能实验教学中心）_生物科学系
通讯作者	Pan, Xuebo
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,325030,China; 2.Key Laboratory of Regenerative Biology,South China Institute for Stem Cell Biology and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510530,China; 3.Department of Biology,School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou, Zhejiang,325030,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Fang, Zhiyuan,Wang, Yu,Li, Hao,et al. Combination Treatment of Citral Potentiates the Efficacy of Hyperthermic Intraperitoneal Chemoperfusion with Pirarubicin for Colorectal Cancer[J]. MOLECULAR PHARMACEUTICS,2017,14(10):3588-3597.
APA	Fang, Zhiyuan., Wang, Yu., Li, Hao., Yu, Shuaishuai., Liu, Ziying., ... & Wang, Cong. (2017). Combination Treatment of Citral Potentiates the Efficacy of Hyperthermic Intraperitoneal Chemoperfusion with Pirarubicin for Colorectal Cancer. MOLECULAR PHARMACEUTICS, 14(10), 3588-3597.
MLA	Fang, Zhiyuan,et al."Combination Treatment of Citral Potentiates the Efficacy of Hyperthermic Intraperitoneal Chemoperfusion with Pirarubicin for Colorectal Cancer".MOLECULAR PHARMACEUTICS 14.10(2017):3588-3597.