Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis

doi:10.1007/s00345-019-02788-6

科研成果详情

题名	Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis
作者	Wei, Yubin 2; Wang, Maofeng3; Jin, Yili2; Zhou, Changchun 2; Lyu, Jia 1
发表日期	2020-06
发表期刊	WORLD JOURNAL OF UROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Overall survival Cancer-specific survival Lymph node dissection Renal cell carcinoma Radical nephrectomy SEER database
其他关键词	CYTOREDUCTIVE NEPHRECTOMY ; CANCER ; LYMPHADENECTOMY ; PROGRESSION ; SERIES
摘要	Background To assess the impact of lymph node dissection (LND) extent on overall survival (OS) and cancer-specific survival (CSS) in patients with pN0M0 renal cell carcinoma (RCC) treated with radical nephrectomy (RN). Materials and methods Data queried for this study include RCC (2010-2014) from the Surveillance, Epidemiology, and End Results (SEER) program. Kaplan-Meier analyses and multivariate Cox regression models tested the effect of number of removed lymph node (NRN) >= 50th percentile on OS and CSS. The associations were evaluated using propensity score (PS) matching adjustment. Results A total of 5532 pN0M0 RCC patients were enrolled in our study. The median NRN was 2 (IQR 1-6), the 50th percentile defined patients with NRN >= 2. Following PS adjustment, there were no significant differences in clinicopathologic features between two groups of patients except for age. Multivariate model analysis showed that patients with NRN < 2 had worse OS than those with NRN >= 2 in pT3 group (HR 1.442; P = 0.032) but not in pT1 and pT2 groups (HR 0.859 and 1.393, P = 0.443 and P = 0.267, respectively). However, patients with NRN < 2 had better CCS than those with NRN >= 2 in pT1 group (HR 0.368; P = 0.016) but not in pT2 and pT3 groups (HR 1.674 and 1.325, P = 0.216 and P = 0.176, respectively). Conclusions More extensive LND (NRN >= 2) at RN is associated with better OS in pT3N0M0 RCC patients while it exerts negative influence on CCS in pT1N0M0 group. Hence, more extensive LND has therapeutic value in pT3 individuals but not in pT1 group.
资助项目	the General Project Funds from the Health Department of Zhejiang Province [2017KY225] Funding Source: Medline
出版者	SPRINGER
出版地	NEW YORK
ISSN	0724-4983
EISSN	1433-8726
卷号	38 期号:6 页码:1579-1585
DOI	10.1007/s00345-019-02788-6
页数	7
WOS类目	Urology & Nephrology
WOS研究方向	Urology & Nephrology
WOS记录号	WOS:000534963200028
收录类别	SCIE ; PUBMED
URL	查看原文
Pubmed记录号	31065795
通讯作者地址	[Lyu, Jia]Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Peoples Hosp, Dept Urol, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China.
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4809
专题	其他_附属东阳医院（东阳市人民医院）
通讯作者	Lyu, Jia
作者单位	1.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Peoples Hosp, Dept Urol, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Dongyang Hosp, Dept Urol, Dongyang 322100, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Dongyang Hosp, Dept Clin Lab, Dongyang 322100, Zhejiang, Peoples R China
第一作者单位	附属东阳医院（东阳市人民医院）
第一作者的第一单位	附属东阳医院（东阳市人民医院）
推荐引用方式 GB/T 7714	Wei, Yubin,Wang, Maofeng,Jin, Yili,et al. Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis[J]. WORLD JOURNAL OF UROLOGY,2020,38(6):1579-1585.
APA	Wei, Yubin, Wang, Maofeng, Jin, Yili, Zhou, Changchun, & Lyu, Jia. (2020). Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis. WORLD JOURNAL OF UROLOGY, 38(6), 1579-1585.
MLA	Wei, Yubin,et al."Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis".WORLD JOURNAL OF UROLOGY 38.6(2020):1579-1585.