Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus

doi:10.1111/jdi.13535

科研成果详情

题名	Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus
作者	Qian, Yuqin 1; Zeng, Yaying 2; Lin, Qingxia3; Huang, Huanjie4; Zhang, Wanli4; Yu, Huan 5; Deng, Binbin4
发表日期	2021-10
发表期刊	JOURNAL OF DIABETES INVESTIGATION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diabetic peripheral neuropathy Nerve conduction study Platelet indices
摘要	Aims/Introduction Diabetes has been considered as a 'pro-thrombotic state' with enhanced platelet reactivity. Abnormality in platelet aggregation has been found in patients with its most common chronic complication - diabetic peripheral neuropathy (DPN). The purpose of this study was to investigate the potential association of platelet indices with nerve conduction function and the presence of DPN in Chinese patients with type 2 diabetes mellitus. Materials and Methods This study involved a total of 211 inpatients with type 2 diabetes mellitus and 55 healthy individuals for whom nerve conduction studies were carried out. DPN was diagnosed according to the American Diabetes Association recommendation. Clinical data were retrospectively collected. Results Patients with diabetes in whom neuropathy developed had lower levels of platelet count (PLT) and plateletcrit (PCT) than healthy controls (P < 0.05). Statistically significant associations of low PLT and PCT levels with the reduction of summed amplitude/velocity Z-score, and the prolongation of F-wave minimum latency in nerve conduction studies were found. Furthermore, after multivariate adjustment, logistic regression analysis showed that low levels of PLT (odds ratio 2.268, 95% confidence interval 1.072-4.797; P < 0.05; PLT <226 vs PLT >= 226) and PCT (odds ratio 2.050, 95% confidence interval 1.001-4.201; P < 0.05; PCT <0.222 vs PCT >= 0.222) in type 2 diabetes mellitus patients were risk factors for the presence of DPN. Conclusions Lower PLT and PCT levels are closely associated with poorer peripheral nerve conduction functions and the presence of neuropathy in patients with type 2 diabetes mellitus, which suggests that PLT and PCT might be potential biomarkers for showing DPN.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81901273]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ21H090018]; Wenzhou Science & Technology Bureau [Y20180492]
出版者	WILEY
出版地	HOBOKEN
ISSN	2040-1116
EISSN	2040-1124
卷号	12 期号:10 页码:1835-1844
DOI	10.1111/jdi.13535
页数	10
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000631347100001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33650778
PMC记录号	PMC8504918
SCOPUSEID	2-s2.0-85102867316
通讯作者地址	[Deng, Binbin]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Internal Medicine;Endocrinology, Diabetes and Metabolism
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4797
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院精神医学学院_精神医学系第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Deng, Binbin
作者单位	1.Department of Neurology,Institute of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 2.First School of Clinical Medicine,Wenzhou Medical University,Wenzhou,China; 3.Department of Psychiatry,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.Department of Pediatrics,Tianjin Children's Hospital,Tianjin,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Qian, Yuqin,Zeng, Yaying,Lin, Qingxia,et al. Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus[J]. JOURNAL OF DIABETES INVESTIGATION,2021,12(10):1835-1844.
APA	Qian, Yuqin., Zeng, Yaying., Lin, Qingxia., Huang, Huanjie., Zhang, Wanli., ... & Deng, Binbin. (2021). Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus. JOURNAL OF DIABETES INVESTIGATION, 12(10), 1835-1844.
MLA	Qian, Yuqin,et al."Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus".JOURNAL OF DIABETES INVESTIGATION 12.10(2021):1835-1844.