Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPAR gamma expression and suppressing inflammatory cytokine levels

doi:10.1016/j.bbrc.2018.09.004

科研成果详情

题名	Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPAR gamma expression and suppressing inflammatory cytokine levels
作者	Liu, Jingjing1; Cai, Gexiang 1; Li, Manxiang 2; Fan, Shiqian 1; Yao, Boyang 1; Ping, Weidong 3; Huang, Zhifeng4; Cai, Hui 1; Dai, Yongyue5; Wang, Liangxing1; Huang, Xiaoying 1
发表日期	2018-10-02
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Pulmonary hypertension Hypoxia Fibroblast growth factor 21 Peroxisome proliferator activated receptor gamma Inflammation
其他关键词	ACTIVATED RECEPTOR-GAMMA ; ARTERIAL-HYPERTENSION ; PATHWAY ; APOPTOSIS ; STRESS ; CELLS ; FGF21 ; MICE
摘要	Hypoxia-induced pulmonary hypertension (HPH) is a progressive disease characterized by a sustained, elevated pulmonary arterial pressure and vascular remodeling. The latter pathogenesis mainly involves overproliferation of pulmonary artery smooth muscle cells (PASMCs). Fibroblast growth factor 21 (FGF21) has recently emerged as a novel regulator that prevents cardiac hypertrophic remodeling. However, its possible role in pulmonary remodeling remains unclear. The activation of peroxisome proliferator activated receptor gamma (PPAR gamma) is reported to attenuate HPH by suppressing proliferative signals. Loss of PPAR gamma in the lung contributes to abnormal proliferation of PASMCs. FGF21 is a key regulator of PPAR gamma activity in adipocytes, but its role has not been elucidated in PASMCs. Therefore, we hypothesized that FGF21 may confer therapeutic effects in HPH by upregulating the expression of PPAR gamma. Sprague-Dawley rats were exposed to hypoxia and treated with FGF21 for 4 weeks. In parallel, hypoxic conditions and FGF21 were administered to rat PASMCs for 48 h. FGF21 attenuated the hypoxia-induced elevation in mean pulmonary arterial pressure (mPAP), right ventricular hypertrophy (RVH), medial thickening and over-proliferation of PASMCs. Furthermore, FGF21 abrogated the reductions in PPAR gamma expression and increases in TNF-alpha, IL-1 and IL-6 levels in PASMC culture media. Collectively, these results demonstrate that FGF21 could potentially attenuate the pathogenic derangements of HPH by targeting PPAR gamma and inflammatory cytokines. (C) 2018 Published by Elsevier Inc.
资助项目	Natural Science Foundation Grants of Zhejiang Province, China [Y17H010028]; Project of Health Department of Zhejiang Province of China [2016DTA005]; Chinese National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81873411]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
出版地	SAN DIEGO
ISSN	0006-291X
EISSN	1090-2104
卷号	504 期号:2 页码:478-484
DOI	10.1016/j.bbrc.2018.09.004
页数	7
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000445975200018
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30197006
SCOPUSEID	2-s2.0-85052958462
通讯作者地址	[Huang, Xiaoying]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Key Laboratory of Heart and Lung,Zhejiang,325000,China
Scopus学科分类	Biophysics;Biochemistry;Molecular Biology;Cell Biology
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4662
专题	药学院（分析测试中心）_生物制药系_生物制药工程附属第一医院基础医学院（机能实验教学中心）_病理学与病理生理学系
通讯作者	Huang, Xiaoying
作者单位	1.Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Key Laboratory of Heart and Lung,Zhejiang,325000,China; 2.Department of Respiratory Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,Shanxi,710061,China; 3.Chinese People's Liberation Army 117 Hospital,Zhejiang,310013,China; 4.Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province,Wenzhou Medical University,Zhejiang,325000,China; 5.Department of Pathophysiology,Wenzhou Medical University,Zhejiang,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Liu, Jingjing,Cai, Gexiang,Li, Manxiang,et al. Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPAR gamma expression and suppressing inflammatory cytokine levels[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,504(2):478-484.
APA	Liu, Jingjing., Cai, Gexiang., Li, Manxiang., Fan, Shiqian., Yao, Boyang., ... & Huang, Xiaoying. (2018). Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPAR gamma expression and suppressing inflammatory cytokine levels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 504(2), 478-484.
MLA	Liu, Jingjing,et al."Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPAR gamma expression and suppressing inflammatory cytokine levels".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 504.2(2018):478-484.