Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study

doi:10.1155/2020/3049098

科研成果详情

题名	Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study
作者	Zhang, Hang1; Zuo, Jing-jing 2; Dong, Si-si1; Lan, Yuan 2; Wu, Chen-wei 1; Mao, Guang-yun2,3; Zheng, Chao1,4
发表日期	2020-03-03
发表期刊	JOURNAL OF DIABETES RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	TANDEM MASS-SPECTROMETRY ; PLASMA ; METABONOMICS ; MS ; NEPHROPATHY ; POPULATION ; MELLITUS ; H-1-NMR ; RISK
摘要	Background and Objectives. Diabetic kidney disease is a leading cause of chronic kidney disease and end-stage renal disease across the world. Early identification of DKD is vitally important for the effective prevention and control of it. However, the available indicators are doubtful in the early diagnosis of DKD. This study is aimed at determining novel sensitive and specific biomarkers to distinguish DKD from their counterparts effectively based on the widely targeted metabolomics approach. Materials and Method. This case-control study involved 44 T2DM patients. Among them, 24 participants with DKD were defined as the cases and another 20 without DKD were defined as the controls. The ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry system was applied for the assessment of the serum metabolic profiles. Comprehensive analysis of metabolomics characteristics was conducted to detect the candidate metabolic biomarkers and assess their capability and feasibility. Result. A total of 11 differential metabolites, including Hexadecanoic Acid (C16:0), Linolelaidic Acid (C18:2N6T), Linoleic Acid (C18:2N6C), Trans-4-Hydroxy-L-Proline, 6-Aminocaproic Acid, L-Dihydroorotic Acid, 6-Methylmercaptopurine, Piperidine, Azoxystrobin Acid, Lysopc 20:4, and Cuminaldehyde, were determined as the potential biomarkers for the DKD early identification, based on the multivariable generalized linear regression model and receiver operating characteristic analysis. Conclusion. Serum metabolites might act as sensitive and specific biomarkers for DKD early detection. Further longitudinal studies are needed to confirm our findings.
资助项目	National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670777]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LZ19H020001]; Zhejiang Basic Public Welfare Research Project [LGF19H260011]; Wenzhou Basic Public Welfare Research Project [Y20180201]; Initial Scientific Research Fund [KYQD170301]; Major Project of the Eye Hospital Wenzhou Medical University [YNZD201602]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6745
EISSN	2314-6753
卷号	2020 页码:3049098
DOI	10.1155/2020/3049098
页数	11
WOS类目	Endocrinology & Metabolism ; Medicine, Research & Experimental
WOS研究方向	Endocrinology & Metabolism ; Research & Experimental Medicine
WOS记录号	WOS:000522403300002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32190695
PMC记录号	PMC7072115
SCOPUSEID	2-s2.0-85082045335
通讯作者地址	[Mao, Guang-yun]Center on Clinical Research,School of Ophthalmology and Optometry,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4234
专题	第二临床医学院、附属第二医院、育英儿童医院公共卫生学院附属第二医院眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_临床与流行病学研究中心
通讯作者	Mao, Guang-yun
作者单位	1.Diabetes Center and Department of Endocrinology,Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,No. 109 West Xueyuan Road,Wenzhou,China; 2.Center on Clinical Research,School of Ophthalmology and Optometry,Wenzhou Medical University,Wenzhou,China; 3.Center on Evidence-Based Medicine,Clinical Epidemiological Research,School of Public Health,Wenzhou Medical University,Wenzhou,China; 4.Second Affiliated Hospital,Zhejiang University,School of Medicine,Hangzhou,China
第一作者单位	附属第二医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Zhang, Hang,Zuo, Jing-jing,Dong, Si-si,et al. Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study[J]. JOURNAL OF DIABETES RESEARCH,2020,2020:3049098.
APA	Zhang, Hang., Zuo, Jing-jing., Dong, Si-si., Lan, Yuan., Wu, Chen-wei., ... & Zheng, Chao. (2020). Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study. JOURNAL OF DIABETES RESEARCH, 2020, 3049098.
MLA	Zhang, Hang,et al."Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study".JOURNAL OF DIABETES RESEARCH 2020(2020):3049098.