Uric acid participating in female reproductive disorders: a review

doi:10.1186/s12958-021-00748-7

科研成果详情

题名	Uric acid participating in female reproductive disorders: a review
作者	Hu, Junhao 1; Xu, Wenyi 1; Yang, Haiyan1; Mu, Liangshan 2
发表日期	2021-04-27
发表期刊	REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Uric acid Polycystic ovary syndrome Endometriosis Pregnancy complications
摘要	Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many diseases has been found. The association between UA and kidney disease and cardiovascular disease is well established; however, there is still a paucity of reviews on the association between UA and the female reproductive system. An increasing number of epidemiological studies have shown elevated serum UA levels in patients with polycystic ovary syndrome (PCOS), endometriosis, etc. Additionally, serum UA can be used as a predictor of pregnancy complications and adverse foetal outcomes. An increasing number of animal experiments and clinical studies have revealed possible mechanisms related to the involvement of UA in certain female reproductive disorders: oxidative stress, chronic inflammation, mitochondrial dysfunction, etc. This article reviews the current mainstream mechanisms regarding the pathogenesis of UA and the role of UA in certain specific female reproductive disorders (direct involvement in the development of certain diseases or enhancement of other risk factors) in the hope of contributing to clinical prevention, diagnosis, treatment and improvement in prognosis.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82001503]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020M671760]
出版者	BMC
出版地	LONDON
ISSN	1477-7827
EISSN	1477-7827
卷号	19 期号:1 页码:65
DOI	10.1186/s12958-021-00748-7
页数	11
WOS类目	Endocrinology & Metabolism ; Reproductive Biology
WOS研究方向	Endocrinology & Metabolism ; Reproductive Biology
WOS记录号	WOS:000644830400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33906696
PMC记录号	PMC8077923
SCOPUSEID	2-s2.0-85105099747
通讯作者地址	[Yang, Haiyan]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,No.96 Fuxue Road,Wenzhou,325000,China ; [Mu, Liangshan]School of Medicine,Zhejiang University,No.866 Yuhantang Road,Hangzhou,310058,China
Scopus学科分类	Reproductive Medicine;Endocrinology;Obstetrics and Gynecology;Developmental Biology
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3944
专题	附属第一医院_生殖医学中心
通讯作者	Yang, Haiyan; Mu, Liangshan
作者单位	1.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,No.96 Fuxue Road,Wenzhou,325000,China; 2.School of Medicine,Zhejiang University,No.866 Yuhantang Road,Hangzhou,310058,China
第一作者单位	附属第一医院_生殖医学中心
通讯作者单位	附属第一医院_生殖医学中心
第一作者的第一单位	附属第一医院_生殖医学中心
推荐引用方式 GB/T 7714	Hu, Junhao,Xu, Wenyi,Yang, Haiyan,et al. Uric acid participating in female reproductive disorders: a review[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2021,19(1):65.
APA	Hu, Junhao, Xu, Wenyi, Yang, Haiyan, & Mu, Liangshan. (2021). Uric acid participating in female reproductive disorders: a review. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 19(1), 65.
MLA	Hu, Junhao,et al."Uric acid participating in female reproductive disorders: a review".REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 19.1(2021):65.