Long-term effects of simultaneous subconjunctival and subscleral mitomycin C application in repeat trabeculectomy

doi:10.1097/00061198-200204000-00006

科研成果详情

题名	Long-term effects of simultaneous subconjunctival and subscleral mitomycin C application in repeat trabeculectomy
作者	You, YA ; Gu, YS ; Fang, CT ; Ma, XQ
发表日期	2002-04
发表期刊	JOURNAL OF GLAUCOMA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	mitomycin trabeculectomy glaucoma
其他关键词	GLAUCOMA FILTRATION SURGERY ; FILTERING SURGERY ; POSTOPERATIVE 5-FLUOROURACIL ; INTRAOPERATIVE MITOMYCIN ; AQUEOUS-HUMOR ; RABBIT ; FIBROBLASTS
摘要	Purpose: To assess the efficacy and safety of simultaneous mitomycin C application under conjunctival and scleral flaps in patients with repeat trabeculectomy. Methods: A total of 44 patients (44 eyes) with previous failed filtering surgery were randomized to one of two groups. The both-flaps group comprised 22 patients (22 eyes) with trabeculectomy and intraoperative mitomycin C application under conjunctival and scleral flaps, whereas the subconjunctival group comprised 22 patients (22 eyes) with subconjunctival application of mitomycin C. Particular attention was paid to intraocular pressure, postoperative medications, visual acuity, filtering bleb appearance, and complications. The mean follow-up time was 38.18 +/- 12.48 months. Results: The mean preoperative intraocular pressure decreased from 39.1 +/- 7.3 mm Hg to the postoperative level of 15.6 +/- 4.8 mm Hg in the both-flaps group (P = 0.014), and from 39.4 +/- 8.4 to 18.7 +/- 5.8 mm Hg in the subconjunctival group (P = 0.018). There was a statistically significant difference in intraocular pressure at all follow-up times, except at 1 week and 1 month postoperatively. Kaplan-Meier survival analysis showed there was no significant difference in total success rate (complete plus qualified success) between the two group, (P = 0.622, log-rank test). However, the two survival curves for the complete success subgroups (without additional medications) confirmed that mitomycin C applications under both flaps had a higher success rate than subconjunctival application (P = 0.043, log-rank test). No statistically significant difference in medications was present between the two groups, and no severe complications developed in either group. Conclusions: Trabeculectomy augmented with mitomycin C application at both sites could produce a greater lowering of intraocular pressure with low incidence of postoperative complications, and could provide an increased chance of long-term success. The procedure is effective and safe in patients with repeat trabeculectomy.
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	1057-0829
卷号	11 期号:2 页码:110-118
DOI	10.1097/00061198-200204000-00006
页数	9
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:000174913000006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	11912358
SCOPUSEID	2-s2.0-0036213912
通讯作者地址	[You, YA]First Affiliated Hosp, Dept Ophthalmol, Wenzhou Med Coll, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计	被引频次：37[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3927
专题	附属第一医院_眼科
通讯作者	You, YA
作者单位	1.First Affiliated Hosp, Dept Ophthalmol, Wenzhou Med Coll, Wenzhou 325000, Zhejiang, Peoples R China; 2.Zhejiang Univ, Coll Med, Dept Ophthalmol, Affiliated Hosp 1, Hangzhou 310027, Zhejiang, Peoples R China
通讯作者单位	眼科
推荐引用方式 GB/T 7714	You, YA,Gu, YS,Fang, CT,et al. Long-term effects of simultaneous subconjunctival and subscleral mitomycin C application in repeat trabeculectomy[J]. JOURNAL OF GLAUCOMA,2002,11(2):110-118.
APA	You, YA, Gu, YS, Fang, CT, & Ma, XQ. (2002). Long-term effects of simultaneous subconjunctival and subscleral mitomycin C application in repeat trabeculectomy. JOURNAL OF GLAUCOMA, 11(2), 110-118.
MLA	You, YA,et al."Long-term effects of simultaneous subconjunctival and subscleral mitomycin C application in repeat trabeculectomy".JOURNAL OF GLAUCOMA 11.2(2002):110-118.