Recent advances in re-engineered liver: de-cellularization and re-cellularization techniques

doi:10.1016/j.jcyt.2015.04.003

科研成果详情

题名	Recent advances in re-engineered liver: de-cellularization and re-cellularization techniques
作者	Wang, Li-Ren 1,2; Lin, Yi-Qian 1,3; Wang, Jiang-Tao1,2; Pan, Liang-Liang4; Huang, Ka-Te5; Wan, Li5; Zhu, Gui-Qi 1,2; Liu, Wen-Yue6; Braddock, Martin 7; Zheng, Ming-Hua1,8
发表日期	2015-08
发表期刊	CYTOTHERAPY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	de-cellularization extracellular matrix organ engineering re-cellularization
其他关键词	REGENERATIVE MEDICINE APPROACH ; PLURIPOTENT STEM-CELLS ; EXTRACELLULAR-MATRIX ; DECELLULARIZED MATRIX ; MACROPHAGE PHENOTYPE ; HEPATOCYTE FUNCTION ; BIOLOGIC SCAFFOLDS ; NATURAL ANTIBODIES ; ENDOTHELIAL-CELLS ; I PROCOLLAGEN
摘要	Allogeneic transplantation is the definitive treatment for patients with end-stage liver disease but is limited by donor shortage and very high cost. Through de-cellularization and re-cellularization methods, re-engineered liver may provide a promising alternative for treating patients with end-stage liver disease. To achieve this, the prevention of the native extracellular matrix ultrastructure plays a central role in de-cellularization protocol; the re-seeding cell types, as well as re-seeding strategies, need more explorations in re-cellularization protocol. Some success of this approach has been published in a rat model; however, the re-engineered liver remains functional in vivo for only several hours, which suggests that the recent protocol may be far from the ideal target. This Review highlights the challenges still to be overcome and presents an overview and summary of methods of de-cellularization and re-cellularization strategies, together with a view on future directions that may lead to the regeneration of a functional liver.
资助项目	Scientific Research Foundation of Wenzhou, Zhejiang Province, China [H20090014, Y20090269]; Health Bureau of Zhejiang Province [2010KYB070]; Research Foundation of Education Bureau of Zhejiang Province [Y201009942]; Fresh Talent Program for Science and Technology Wenzhou Medical University [wyx201401011, wyx201401087, wyx201401009, wyx201401085]; Research Funds for Tian Qing Liver Diseases [TQGB20120057]; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	1465-3249
EISSN	1477-2566
卷号	17 期号:8 页码:1015-1024
DOI	10.1016/j.jcyt.2015.04.003
页数	10
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Hematology ; Medicine, Research & Experimental
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology ; Hematology ; Research & Experimental Medicine
WOS记录号	WOS:000357842900002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25981396
SCOPUSEID	2-s2.0-84937629069
通讯作者地址	[Zheng, Ming-Hua]Department of Infection and Liver Diseases,Liver Research Center,Institute of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Immunology and Allergy;Immunology;Oncology;Genetics (clinical);Cell Biology;Cancer Research;Transplantation
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3897
专题	第一临床医学院（信息与工程学院）、附属第一医院检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_病理科仁济学院附属第一医院_内分泌科
通讯作者	Zheng, Ming-Hua
作者单位	1.Department of Infection and Liver Diseases,Liver Research Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Renji School of Wenzhou Medical University,Wenzhou,China; 4.School of Laboratory and Life Science,Wenzhou Medical University,Wenzhou,China; 5.Department of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 7.Global Medicines Development,AstraZeneca R and D,Alderley Park,United Kingdom; 8.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Li-Ren,Lin, Yi-Qian,Wang, Jiang-Tao,et al. Recent advances in re-engineered liver: de-cellularization and re-cellularization techniques[J]. CYTOTHERAPY,2015,17(8):1015-1024.
APA	Wang, Li-Ren., Lin, Yi-Qian., Wang, Jiang-Tao., Pan, Liang-Liang., Huang, Ka-Te., ... & Zheng, Ming-Hua. (2015). Recent advances in re-engineered liver: de-cellularization and re-cellularization techniques. CYTOTHERAPY, 17(8), 1015-1024.
MLA	Wang, Li-Ren,et al."Recent advances in re-engineered liver: de-cellularization and re-cellularization techniques".CYTOTHERAPY 17.8(2015):1015-1024.