STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane

doi:10.1097/WNR.0000000000000509

科研成果详情

题名	STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane
作者	Yang, Yan 1; Song, Shiyu 1; Min, Haiyan 1; Chen, Xiufang 2; Gao, Qian 1
发表日期	2016-01-20
发表期刊	NEUROREPORT 影响因子和分区
语种	英语
原始文献类型	Article
关键词	calcineurin isoflurane neurotoxicity signal transducer and activator of transcription-3
其他关键词	HIPPOCAMPAL-NEURONS ; NERVOUS-SYSTEM ; EARLY EXPOSURE ; VOLATILE ANESTHETICS ; MEMORY IMPAIRMENT ; SIGNAL TRANSDUCER ; ACTIVATION ; CALCIUM ; NEURODEGENERATION ; VULNERABILITY
摘要	Isoflurane, a commonly used volatile anesthetic, causes widespread neuronal apoptosis in the developing brain of rodents. Signal transducer and activator of transcription-3 (STAT3) signaling is crucial for cell survival during the neural network establishment period. The aim of this study was to determine whether isoflurane would target STAT3 to deliver its neurotoxicity. Mice at postnatal day 7 and primary cortical neurons cultured for 5 days were treated with isoflurane. Our data showed that isoflurane exposure downregulated the STAT3 survival pathway in the brain of mice and in primary neurons, whereas the mRNA levels of STAT3 remained unchanged after isoflurane exposure. We found that inhibiting the activity of calcineurin, which specifically promotes STAT3 degradation, alleviated isoflurane-induced neural apoptosis. Further studies showed that isoflurane increased calcineurin activity and that the inositol 1,4,5-trisphosphate-sensitive Ca2+ channel was involved in these isoflurane-induced molecular cascades. These findings suggest that isoflurane-induced neurotoxicity may stem from STAT3 degradation, partially through the activation of calcineurin. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [8157041339, 021414380069]
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0959-4965
EISSN	1473-558X
卷号	27 期号:2 页码:124-130
DOI	10.1097/WNR.0000000000000509
页数	7
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000373507400012
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	26694943
SCOPUSEID	2-s2.0-84952660591
通讯作者地址	[Gao, Qian]Center for Translational Medicine,Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing, Jiangsu,210093,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3893
专题	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
通讯作者	Gao, Qian
作者单位	1.Center for Translational Medicine,Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing, Jiangsu,210093,China; 2.Department of Biochemistry,Wenzhou Medical University,Wenzhou, Zhejiang,China
推荐引用方式 GB/T 7714	Yang, Yan,Song, Shiyu,Min, Haiyan,et al. STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane[J]. NEUROREPORT,2016,27(2):124-130.
APA	Yang, Yan, Song, Shiyu, Min, Haiyan, Chen, Xiufang, & Gao, Qian. (2016). STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. NEUROREPORT, 27(2), 124-130.
MLA	Yang, Yan,et al."STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane".NEUROREPORT 27.2(2016):124-130.