Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma

doi:10.1111/cen.12417

科研成果详情

题名	Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma
作者	Yang, Yinlong1,2; Chen, Chengze2; Chen, Zimiao3; Jiang, Jiachun4; Chen, Yizuo2; Jin, Langping 2; Guo, Guilong2; Zhang, Xiaohua 2; Ye, Tingting3
发表日期	2014-08
发表期刊	CLINICAL ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	BRAF MUTATION ; LYMPHOCYTIC THYROIDITIS ; RISK-FACTORS ; NECK ; CANCER ; RECURRENCE ; MANAGEMENT ; CARCINOMA ; ASSOCIATION ; DIAGNOSIS
摘要	Objectives We aimed to determine the predictive factors for central compartment lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC). Design and patients We undertook a retrospective study of 291 patients treated for PTMC. The following criteria were assessed to predict the presence of central compartment LNM: sex, age, tumour multifocality, tumour size, tumour bilaterality, extracapsular spread (ECS), lateral neck LNM, coexistence of chronic lymphocytic thyroiditis, BRAF(V600E) mutation and ultrasonography (US) features. Univariate and multivariate analyses were performed to identify clinicopathological characteristics and US findings in predicting central compartment LNM from PTMC. Results The central compartment LNM affected 133 (45.7%) of 291 patients. With use of univariate and multivariate analyses, male gender (OR 2.020; P = 0.039), tumour size (>5 mm) (OR 3.687; P = 0.015), ESC (OR 2.330; P = 0.044), lateral LNM (OR 15.075; P = 0.000) and BRAF(V600E) mutation (OR 2.464; P = 0.000) were independently correlated with central compartment LNM. Age, tumour multifocality, tumour bilaterality, coexistence of chronic lymphocytic thyroiditis and US characteristics were not significantly related to the presence of central compartment LNM. We have also developed a nomogram to predict the probability of central compartment LNM for an individual patient. The sensitivity was 71.9% and specificity was 70.3%, with an under the receiver operating characteristic (ROC) curve of 0.772. Conclusions A prophylactic neck dissection of the central compartment should be considered particularly in PTMC patients with male gender, a > 5 mm tumour size, ECS of the tumours, lateral LNM and positive BRAF(V600E) mutation.
出版者	WILEY
出版地	HOBOKEN
ISSN	0300-0664
EISSN	1365-2265
卷号	81 期号:2 页码:282-288
DOI	10.1111/cen.12417
页数	7
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000339670500020
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	24483297
Scopus记录号	2-s2.0-84904394625
通讯作者地址	[Yang, Yinlong]Department of Breast Surgery, Shanghai Medical College, Fudan University,China
scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：70[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3776
专题	附属第一医院_肿瘤外科附属第一医院_内分泌科
通讯作者	Yang, Yinlong
作者单位	1.Department of Breast Surgery, Shanghai Medical College, Fudan University,China; 2.Department of Surgical Oncology, First Affiliated Hospital of Wenzhou Medical University,China; 3.Department of Endocrinology, First Affiliated Hospital of Wenzhou Medical University,China; 4.Department of Ultrasound, First Affiliated Hospital of Wenzhou Medical University,China
第一作者单位	附属第一医院; 肿瘤外科
推荐引用方式 GB/T 7714	Yang, Yinlong,Chen, Chengze,Chen, Zimiao,et al. Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma[J]. CLINICAL ENDOCRINOLOGY,2014,81(2):282-288.
APA	Yang, Yinlong., Chen, Chengze., Chen, Zimiao., Jiang, Jiachun., Chen, Yizuo., ... & Ye, Tingting. (2014). Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma. CLINICAL ENDOCRINOLOGY, 81(2), 282-288.
MLA	Yang, Yinlong,et al."Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma".CLINICAL ENDOCRINOLOGY 81.2(2014):282-288.