Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy

doi:10.1016/j.urolonc.2018.12.027

科研成果详情

题名	Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy
作者	Zeng, Shuxiong 1; Dai, Lihe 1; Yang, Jun 1; Gao, Xiaomin 1; Yu, Xiaowen 2; Ren, Qian 1; Wang, Kaijian 1; Xu, Jinshan 1; Yang, Zeyu 1; Yang, Bo 1; Wang, Huiqing 1; Yang, Qing 1; Ye, Huamao 1; Hou, Jianguo 1; Pan, Yue3; Zhang, Zhensheng 1; Weng, Zhiliang3; Sun, Yinghao 1; Xu, Chuanliang 1
发表日期	2019-04
发表期刊	UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Nomogram Predictors Prognosis Upper tract urothelial carcinoma
其他关键词	CISPLATIN-INELIGIBLE PATIENTS ; ADJUVANT CHEMOTHERAPY ; EUROPEAN ASSOCIATION ; SINGLE-ARM ; SURVIVAL ; OUTCOMES ; BLADDER ; IMPACT ; DIFFERENTIATION ; MULTICENTER
摘要	Objective: To create multivariable models with readily available clinicopathologic variables for predicting the prognosis of upper tract urothelial carcinomas (UTUC). Patients and methods: We retrospectively analyzed patients diagnosed as UTUC and underwent radical nephroureterectomy in 2 high volumes, tertiary care centers. A total of 445 patients and 227 patients met the inclusion criteria were included for constructing the prediction model and external validation, respectively. Univariable and multivariable Cox regression models were used to analyze independent risk factors, and nomogram and calibration curve were constructed by R project. Results: The median follow-up for the development and external validation cohorts were 33.5 and 32.5 months, respectively. Multivariable analysis detected older age (>= 65 years), with concurrent bladder cancer at diagnosis, with both ureter and renal pelvic tumor, lymphovascular invasion, urothelial carcinoma with divergent differentiation, higher pathological grade and stage, and positive lymph node were significantly associated with poorer outcome of UTUC. The c-index of the nomogram with these above-mentioned independent risk factors to predict the cancer specific survival was 0.74 (95% CI, 0.64-0.84) and 0.73 (95% CI, 0.59-0.87) for the development cohort and external validation cohort, respectively. Conclusions: We developed and externally validated a novel and accurate nomogram with readily available clinicopathological information for predicting the cancer specific survival of UTUC. This nomogram could help clinicians stratify patients with UTUC into different risk groups with distinct prognosis by the total scores obtained from the prediction tool, thus facilitate decision-making and clinical trial designing. (C) 2018 Elsevier Inc. All rights reserved.
资助项目	Shanghai Sailing Program [18YF1422700]; Starting Foundation for Young Scientists of Second Military Medical University [2017QN10, 2017QN11]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81772720, 81572509, 81802515, 81801854]
出版者	ELSEVIER SCIENCE INC
出版地	NEW YORK
ISSN	1078-1439
EISSN	1873-2496
卷号	37 期号:4 页码:290.e17-290.e24.
DOI	10.1016/j.urolonc.2018.12.027
页数	8
WOS类目	Oncology ; Urology & Nephrology
WOS研究方向	Oncology ; Urology & Nephrology
WOS记录号	WOS:000462158500009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30630733
SCOPUSEID	2-s2.0-85059521035
通讯作者地址	[Sun, Yinghao]Department of Urology,Changhai Hospital,Second Military Medical University,Shanghai,China
Scopus学科分类	Oncology;Urology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3714
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_泌尿外科
通讯作者	Sun, Yinghao
作者单位	1.Department of Urology,Changhai Hospital,Second Military Medical University,Shanghai,China; 2.Department of Geriatrics,Changhai Hospital,Second Military Medical University,Shanghai,China; 3.Department of Urology,The First Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Zeng, Shuxiong,Dai, Lihe,Yang, Jun,et al. Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy[J]. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,2019,37(4):290.e17-290.e24..
APA	Zeng, Shuxiong., Dai, Lihe., Yang, Jun., Gao, Xiaomin., Yu, Xiaowen., ... & Xu, Chuanliang. (2019). Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 37(4), 290.e17-290.e24..
MLA	Zeng, Shuxiong,et al."Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy".UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 37.4(2019):290.e17-290.e24..