HPV6b virus like particles are potent immunogens without adjuvant in man

doi:10.1016/S0264-410X(99)00351-5

科研成果详情

题名	HPV6b virus like particles are potent immunogens without adjuvant in man
作者	Zhang, LF ; Zhou, J ; Chen, S ; Cai, LL ; Bao, QY ; Zheng, FY ; Lu, JQ ; Padmanabha, J ; Hengst, K ; Malcolm, K ; Frazer, IH
发表日期	2000-01-06
发表期刊	VACCINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	papillomavirus vaccines virus like particles
其他关键词	COTTONTAIL RABBIT PAPILLOMAVIRUS ; LEUKOCYTE INTERFERON-ALPHA ; IMMUNE-RESPONSE MODIFIER ; CONDYLOMATA ACUMINATA ; GENITAL WARTS ; DOUBLE-BLIND ; EPITHELIAL-CELLS ; CAPSID PROTEIN ; L1 PROTEIN ; IMMUNIZATION
摘要	Subjects with genital warts were immunized three times or more with HPV6b VLPs without adjuvant. All immunized subjects had DTH to HPV6b L1 protein. Of 32 subjects, nine had HPV6b specific antibody prior to immunization and 22 acquired antibody with immunization. VLP specific antibody increased following a single immunization in 6 of 8 subjects with low level antibody at recruitment. Complete regression of genital warts was observed in 25 of 33 evaluable subjects over the 20-week observation period. We conclude that immunization with HPV6b L1 VLPs without adjuvant induces immunity to the L1 protein epitopes recognised during natural infection, and may accelerate regression of warts. (C) 2000 Elsevier Science Ltd. All rights reserved.
资助项目	International Union Against Cancer[undefined];
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0264-410X
EISSN	1873-2518
卷号	18 期号:11-12 页码:1051-1058
DOI	10.1016/S0264-410X(99)00351-5
页数	8
WOS类目	Immunology ; Medicine, Research & Experimental
WOS研究方向	Immunology ; Research & Experimental Medicine
WOS记录号	WOS:000084600000004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	10590325
SCOPUSEID	2-s2.0-0344771067
引用统计	被引频次：132[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3652
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学微生物学
作者单位	1.Univ Queensland, Princess Alexandra Hosp, Ctr Immunol & Canc Res, Brisbane, Qld 4102, Australia; 2.Wenzhou Med Coll, Dept Microbiol, Wenzhou 325003, Zhejiang, Peoples R China; 3.Wenzhou Med Coll, Dept Obstet Gynaecol, Wenzhou 325003, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, LF,Zhou, J,Chen, S,et al. HPV6b virus like particles are potent immunogens without adjuvant in man[J]. VACCINE,2000,18(11-12):1051-1058.
APA	Zhang, LF., Zhou, J., Chen, S., Cai, LL., Bao, QY., ... & Frazer, IH. (2000). HPV6b virus like particles are potent immunogens without adjuvant in man. VACCINE, 18(11-12), 1051-1058.
MLA	Zhang, LF,et al."HPV6b virus like particles are potent immunogens without adjuvant in man".VACCINE 18.11-12(2000):1051-1058.