Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke

doi:10.1177/1756285616681943

科研成果详情

题名	Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke
作者	Yi, Xingyang 1; Han, Zhao2; Zhou, Qiang 3; Lin, Jing3; Wang, Chun 1
发表日期	2017-03
发表期刊	THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	aspirin resistance genetic variants ischemic stroke outcome pharmacogenetics
其他关键词	GENETIC POLYMORPHISMS ; PLATELET ACTIVATION ; RESISTANCE ; P2Y(12) ; RISK ; DETERIORATION
摘要	Background:The effect of gene variants and their interactions on response to aspirin and clinical adverse outcomes after an acute ischemic stroke (IS) is not fully understood. The aim of this study was to investigate the association of aspirin-relevant gene variants and their interactions with clinical adverse outcomes in IS patients taking aspirin. Methods:A total of 14 variants from six genes encoding COX enzymes (COX-1, COX-2), platelet membrane receptors (TXAS1, P2Y1, P2Y12) and glycoprotein receptor (GPIIIa) were examined in 850 acute IS patients. Gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) analysis. All patients were followed up for 1 year after admission. Primary outcome was a composite of recurrent ischemic stroke (RIS), myocardial infarction (MI) and death. Results:The primary outcome occurred in 112 (13.5%) patients (81 RIS, 16 MI and 15 deaths). There were no significant differences in the frequencies of the genotypes of the 14 variants between the patients with and without primary outcome using single-locus analytical approach. However, there was significant gene-gene interaction among rs20417, rs1371097 and rs2317676. The high-risk interactive genotypes of rs20417, rs1371097 and rs2317676 were independently associated with primary adverse outcome of RIS, MI, and death after acute IS. Conclusion:The three-loci interactions are associated with sensitivity of IS patients to aspirin and aspirin-induced adverse clinical events. The combinatorial analysis used in this study may be helpful to elucidate complex genetic risk of aspirin resistance (AR).
资助项目	Deyang City Science and Technology Research Foundation [2014SZ035]; Scientific Research Foundation of Chengdu University of Traditional Chinese Medicine [YYZX1510]
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	1756-2856
EISSN	1756-2864
卷号	10 期号:3 页码:161-170
DOI	10.1177/1756285616681943
页数	10
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000396212700002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28344655
PMC记录号	PMC5349374
SCOPUSEID	2-s2.0-85015017122
通讯作者地址	[Yi, Xingyang]Department of Neurology,People's Hospital of Deyang City,173 North Taishan Road,Deyang, Sichuan,618000,China
Scopus学科分类	Pharmacology;Neurology;Neurology (clinical)
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3598
专题	第二临床医学院、附属第二医院、育英儿童医院_神经病学_神经内科其他_附属第三医院（瑞安市人民医院）
通讯作者	Yi, Xingyang
作者单位	1.Department of Neurology,People's Hospital of Deyang City,173 North Taishan Road,Deyang, Sichuan,618000,China; 2.Department of Neurology,2nd Affiliated Hospital and Yuying Children Hospital,Wenzhou Medical University,No 109, Xueyuan West Road,Wenzhou, Zhejiang,325027,China; 3.Department of Neurology,Third Affiliated Hospital,Wenzhou Medical College,Wenzhou, Zhejiang,China
推荐引用方式 GB/T 7714	Yi, Xingyang,Han, Zhao,Zhou, Qiang,et al. Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke[J]. THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS,2017,10(3):161-170.
APA	Yi, Xingyang, Han, Zhao, Zhou, Qiang, Lin, Jing, & Wang, Chun. (2017). Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke. THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 10(3), 161-170.
MLA	Yi, Xingyang,et al."Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke".THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS 10.3(2017):161-170.