The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction

doi:10.1039/c8ra10542a

科研成果详情

题名	The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction
作者	Zhang, Chunhong 1; Liu, Jia 2,5; Tao, Fengxing 2; Lu, Yiyi 2; He, Qin 2; Zhao, Liang 3; Ou, Rongying 4; Xu, Yunsheng2; Li, Wenfeng3
发表日期	2019
发表期刊	RSC Advances 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Chemotherapy Diseases Mitochondria Tumors Antitumor effect Apoptosis pathways Cervical cancer cells Cytotoxic effects Induced apoptosis Mitochondrial dysfunction Mitochondrial membrane potential Molecular mechanism
其他关键词	TR3/NUR77 ; PROGRESSION ; INHIBITION ; INDUCTION ; GROWTH
摘要	At present, chemotherapy is still the main treatment for cervical cancer. However, the drug resistance of chemotherapy drugs seriously restricts its use, so it is urgent to develop new drugs for cervical cancer. Some studies have shown that gambogic acid has a strong anti-tumor effect, while the anti-tumor effect and molecular mechanism of gambogic acid on cervical cancer need to be studied. Our study confirms that the cytotoxic effect of gambogic acid on cervical cancer cells depends on the expression of TR3 protein. Moreover, gambogic acid-induced apoptosis requires TR3 expression. In the mechanism, gambogic acid promoted nuclear export of TR3, resulting in up-regulation of p53, which leads to the decrease of mitochondrial membrane potential, eventually inducing apoptosis. These results suggest that the nuclear export of TR3 mediated gambogic acid-induced apoptosis through a p53-dependent apoptosis pathway. © 2019 The Royal Society of Chemistry.
资助项目	National Natural Science Foundation of China[81571395,81671408,81771531];
出版者	Royal Society of Chemistry
ISSN	2046-2069
EISSN	2046-2069
卷号	9 期号:21 页码:11855-11864
DOI	10.1039/c8ra10542a
页数	10
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000466757100031
收录类别	EI ; SCOPUS ; PUBMED ; SCIE
EI入藏号	20191706829312
EI主题词	Cell death
URL	查看原文
PubMed ID	35516982
SCOPUSEID	2-s2.0-85064685523
通讯作者地址	[Xu, Yunsheng]Department of Dermatovenereology,First Affliated Hospital of Wenzhou Medical University,Nanbaixiang Street,Wenzhou, Zhejiang Province,China
Scopus学科分类	Chemistry (all);Chemical Engineering (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/35058
专题	附属第一医院_药学部药学部眼视光学院（生物医学工程学院）、附属眼视光医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学第一临床医学院（信息与工程学院）、附属第一医院_皮肤病与性病学_皮肤性病科
通讯作者	Xu, Yunsheng
作者单位	1.Department of Pharmacy,First Affliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China; 2.Department of Dermatovenereology,First Affliated Hospital of Wenzhou Medical University,Nanbaixiang Street,Wenzhou, Zhejiang Province,China; 3.Laboratory for Advanced Interdisciplinary Research,Institute of Translational Medicine,First Affliated Hospital of Wenzhou Medical University,Nanbaixiang Street,Wenzhou, Zhejiang Province,China; 4.Department of Gynaecology and Obstetrics,First Affliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China; 5.Plastic and Cosmetic Center,Affiliated Eye Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhang, Chunhong,Liu, Jia,Tao, Fengxing,et al. The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction[J]. RSC Advances,2019,9(21):11855-11864.
APA	Zhang, Chunhong., Liu, Jia., Tao, Fengxing., Lu, Yiyi., He, Qin., ... & Li, Wenfeng. (2019). The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction. RSC Advances, 9(21), 11855-11864.
MLA	Zhang, Chunhong,et al."The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction".RSC Advances 9.21(2019):11855-11864.