Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation

doi:10.3109/03091902.2011.629276

科研成果详情

题名	Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation
作者	Bao F.1; Jiang L.1; Wang X.2; Zhang D.3; Wang Q.1; Zeng Y.2
发表日期	2012
发表期刊	Journal of Medical Engineering and Technology 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Biomechanics Dynamic loads Elastic moduli Mammals Stiffness Strain Stresses Biomechanical parameters Biomechanical properties Constitutive relationships Cornea Dynamic loading conditions Laser displacement sensors Stress/strain relationships Xenotransplantation
摘要	Objective: This study aims to obtain the biomechanical properties of porcine cornea so as to provide necessary biomechanical experimental basis for pig-to-human corneal xenotransplantation. Methods: Seventeen fresh porcine corneal specimens obtained from pigs aged 4-6 months were examined under inflation conditions to determine the constitutive relationships of the material through dynamic loading conditions (pressure range: 1.47-42.66 mmHg). The forward deflection of porcine anterior corneal apex was measured by the laser displacement sensor. The pressure deformation results were analysed on the basis of shell theory to estimate Young's modulus of the cornea and derive its relationship with intraocular pressure (IOP). Results: The porcine corneas showed a nonlinear corneal forward displacement/IOP and stress/strain relationship with an initial low stiffness stage and a later high stiffness stage. In spite of the nonlinearity between the internal pressure and apex forward deflection, the relationship between the Young's modulus and the IOP was almost linear. Conclusions: Compared with human corneas, porcine corneas exhibited a similar nonlinear behaviour but lower stiffness values. The biomechanical parameters of porcine cornea obtained from this test could be applied to numerical simulations of refractive surgery procedures and lay a foundation for pig-to-human corneal xenotransplantation. © 2012 Informa UK, Ltd.
出版者	Informa Healthcare
ISSN	0309-1902
EISSN	1464-522X
卷号	36 期号:1 页码:17-21
DOI	10.3109/03091902.2011.629276
收录类别	EI ; PUBMED ; SCOPUS
EI入藏号	20115214649299
EI主题词	Stress-strain curves
URL	查看原文
PubMed ID	22085017
SCOPUSEID	2-s2.0-84455170835
通讯作者地址	[Wang Q.]Affiliated Eye Hospital of Wenzhou Medical College,China
Scopus学科分类	Biomedical Engineering
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/35019
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Wang Q.
作者单位	1.Affiliated Eye Hospital of Wenzhou Medical College,China; 2.Beijing University of Technology,China; 3.Department of Mechanics,Shanghai University,Shanghai Institute of Applied Mathematics and Mechanics,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Bao F.,Jiang L.,Wang X.,et al. Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation[J]. Journal of Medical Engineering and Technology,2012,36(1):17-21.
APA	Bao F., Jiang L., Wang X., Zhang D., Wang Q., & Zeng Y.. (2012). Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation. Journal of Medical Engineering and Technology, 36(1), 17-21.
MLA	Bao F.,et al."Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation".Journal of Medical Engineering and Technology 36.1(2012):17-21.