| Title | Finishing the euchromatic sequence of the human genome |
| Creator | |
| Date Issued | 2004-10-21 |
| Source Publication | Nature Impact Factor & Quartile |
| language | 英语 |
| Original Document Type | Journal article (JA) |
| Keyword | Biomedical engineering Genes Physiology Proteins Research Biological analysis Euchromatic sequence Genome sequence Nucleotides |
| Abstract | The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead. |
| Funding Project | National Institutes of Health[U54HG003273]; |
| Publisher | Nature Publishing Group |
| ISSN | 0028-0836 |
| Volume | 431Issue:7011Pages:931-945 |
| DOI | 10.1038/nature03001 |
| Page Number | 71 |
| Indexed By | EI ; SCOPUS |
| EI Accession Number | 2004468458647 |
| EI Keywords | Genetic engineering |
| URL | 查看原文 |
| PubmedId | 15496913 |
| scopuseid | 2-s2.0-7244245762 |
| CNS Important Paper | CNS重要论文 |
| User Journal Classification | T1类 |
| scopus subject classification | Multidisciplinary |
| Top Journal | TOP期刊 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | https://kms.wmu.edu.cn/handle/3ETUA0LF/34890 |
| Recommended Citation GB/T 7714 | Collins, F.S.,Lander, E.S.,Rogers, J.,et al. Finishing the euchromatic sequence of the human genome[J]. Nature,2004,431(7011):931-945. |
| APA | Collins, F.S., Lander, E.S., Rogers, J., & Waterson, R.H.. (2004). Finishing the euchromatic sequence of the human genome. Nature, 431(7011), 931-945. |
| MLA | Collins, F.S.,et al."Finishing the euchromatic sequence of the human genome".Nature 431.7011(2004):931-945. |
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