Fluorescence in situ hybridization detection of peripheral lymphocyte and ultrastructural study of the testicular tissue in a 48,XXYY syndrome patient

科研成果详情

题名	Fluorescence in situ hybridization detection of peripheral lymphocyte and ultrastructural study of the testicular tissue in a 48,XXYY syndrome patient
作者	Liu, Yong-Zhang1; Zhu, Hai-Bo2
发表日期	2003-10-01
发表期刊	Chinese Journal of Medical Genetics 影响因子和分区
语种	中文
原始文献类型	Journal article (JA)
关键词	Blood Cells Collagen Fluorescence Pathology Tissue Cell formation
摘要	Objective: To investigate the pathogenesis of male sterility in 48, XXYY syndrome patient. Methods: The peripheral lymphocyte was detected by dual-color fluorescence in situ hybridization. The bioptic testicular tissues were pathologically sectioned and ultra-thin sections were examined by electron-microscopy. Results: The pathological findings revealed extremely severe dysgenesis of the badly damaged testicular tissue. Only a few convoluted seminiferous tubules were found, in which no spermatogenic cell or sperm of any range could be viewed. The ultrastructural observations showed the thickened interstitial vascular walls of the testicular tissue and severe hyperplasia of the collagen fibers in the basilemma and lumens of the blood vessels. Conclusion: The structure of the testicle in the 48,XXYY syndrome patient has severe fibrous hyperplasia, leading to the non-specific thickening of the barrier and serious damage to the blood-testis barrier, which in turn produce significant disturbance and pathological changes in the process of the spermatogenic cell formation. The whole interrelated loops account mainly for the male sterility.
出版者	West China University of Medical Sciences
ISSN	1003-9406
卷号	20 期号:5 页码:433-435
页数	10
收录类别	EI ; PUBMED ; SCOPUS
EI入藏号	2003447697665
EI主题词	Genetic engineering
URL	查看原文
PubMed ID	14556200
SCOPUSEID	2-s2.0-0142043508
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34887
专题	基础医学院（机能实验教学中心）_生物科学系附属第二医院_泌尿外科
作者单位	1.Department of Biology, Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, China; 2.Department of Urology, Second Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, China
第一作者单位	生物科学系
第一作者的第一单位	生物科学系
推荐引用方式 GB/T 7714	Liu, Yong-Zhang,Zhu, Hai-Bo. Fluorescence in situ hybridization detection of peripheral lymphocyte and ultrastructural study of the testicular tissue in a 48,XXYY syndrome patient[J]. Chinese Journal of Medical Genetics,2003,20(5):433-435.
APA	Liu, Yong-Zhang, & Zhu, Hai-Bo. (2003). Fluorescence in situ hybridization detection of peripheral lymphocyte and ultrastructural study of the testicular tissue in a 48,XXYY syndrome patient. Chinese Journal of Medical Genetics, 20(5), 433-435.
MLA	Liu, Yong-Zhang,et al."Fluorescence in situ hybridization detection of peripheral lymphocyte and ultrastructural study of the testicular tissue in a 48,XXYY syndrome patient".Chinese Journal of Medical Genetics 20.5(2003):433-435.