[A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]

doi:10.7507/1001-5515.201801001

科研成果详情

题名	[A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]
其他题名	A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children
作者	Jiaxiu Zhou 1; Yingxue Gao 2; Xuan Bu 2; Hailong Li 2; Yan Liang 3; Hong Chen3; Meihao Wang4; Feifei Lin 5; Chuang Yang6; Xiaoqi Huang 2
发表日期	2018-06-25
发表期刊	Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 影响因子和分区
语种	英语
原始文献类型	期刊论文
关键词	attention-deficit/hyperactivity disorder degree centrality functional magnetic resonance imaging regional homogeneity voxel-mirrored homotopic connectivity.
摘要	A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.
其他摘要	A great number of studies have demonstrated functional abnormalities in children with attentiondeficit/ hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naive ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.
资助项目	国家自然科学基金面上项目 ; 浙江省自然科学基金 ; 深圳市未来产业专项资金 ; 四川省青年科技基金
ISSN	1001-5515
卷号	35 期号:3 页码:415-420.
DOI	10.7507/1001-5515.201801001
页数	6
收录类别	PUBMED ; CSCD ; 万方 ; PKU ; 北大核心 ; ISTIC ; EI
学科领域	医药、卫生 ; 临床医学 ; 神经病学与精神病学
URL	查看原文
CSCD记录号	CSCD:6256722
PubMed ID	29938950
万方分类号	R749.94(精神病学) ; B844.1(发展心理学(人类心理学)) ; G442(教育心理学)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34833
专题	附属第一医院_精神卫生科第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
作者单位	1.Department of Psychology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.; 2.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.; 3.Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.; 4.Radiology Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.; 5.Radiology Department, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.; 6.Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.dryangchuang@163.com.
推荐引用方式 GB/T 7714	Jiaxiu Zhou,Yingxue Gao,Xuan Bu,et al. [A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children][J]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi,2018,35(3):415-420..
APA	Jiaxiu Zhou., Yingxue Gao., Xuan Bu., Hailong Li., Yan Liang., ... & Xiaoqi Huang. (2018). [A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 35(3), 415-420..
MLA	Jiaxiu Zhou,et al."[A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]".Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 35.3(2018):415-420..

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