Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: An updated meta-analysis

doi:10.3109/08916934.2014.962025

科研成果详情

题名	Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: An updated meta-analysis
作者	Shen, Xiaokun 1,2; Yan, Xingqiang 1; Xie, Bojian1; Xu, Dong1; Wang, Kuifeng 4; Zhu, Jiansheng4; Li, Jichen 2; Zhang, Xiaohua 3; Cao, Feilin1
发表日期	2015-03
发表期刊	AUTOIMMUNITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Graves' disease Hashimoto's thyroiditis interleukin-4 meta-analysis polymorphism
其他关键词	GRAVES-DISEASE ; PROMOTER POLYMORPHISMS ; ASSOCIATION ; SUSCEPTIBILITY ; JAPANESE ; ASTHMA ; PATHOGENESIS ; GENOTYPE ; ATOPY ; IL-4
摘要	Autoimmune thyroid diseases (AITDs) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are common autoimmune endocrine disorders. Interleukin-4 (IL-4), a cytokine secreted by T cells, plays a critical role in antigen-specific Th2 responses. The IL-4 gene is highly polymorphic and it has been reported that the polymorphism at -590 (T/C, rs2243250) in the promoter region of IL-4 may contribute to the development of AITDs. Recently, several case-control studies have examined the association of genetic variants of IL-4 with AITDs. However, the results of these studies remain conflicting. To systematically study the role of IL-4 in the pathogenesis of AITDs, we conducted a meta-analysis including 11 eligible studies (1847 cases and 2068 healthy controls). Fixed-effect or random-effect models were used to calculate pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Our results revealed a significant association between the IL-4 genetic variant (-590, T/C, rs2243250) and the risk of developing AITDs (TC + TT versus TT genotype: OR = 1.83, 95% CI = 1.083-3.091, p = 0.024). These findings demonstrate that the IL-4 rs2243250 genetic variant might play a key role in the development of AITDs.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202103, 31370810, 81472714]; Zhejiang Postdoctoral Science FoundationChina Postdoctoral Science Foundation [Bsh1202065]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0891-6934
EISSN	1607-842X
卷号	48 期号:2 页码:129-135
DOI	10.3109/08916934.2014.962025
页数	7
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:000351610300009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25286078
SCOPUSEID	2-s2.0-84924975767
通讯作者地址	[Li, Jichen]Institute of Cell Biology,School of Medicine,Zhejiang University,No. 388, Yuhangtang Road,Hangzhou,310058,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3476
专题	其他_附属台州医院（浙江省台州医院）附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Li, Jichen
作者单位	1.Department of Surgical Oncology,Taizhou Hospital,Wenzhou Medical University,No. 150, Ximen Road,Taizhou,317000,China; 2.Institute of Cell Biology,School of Medicine,Zhejiang University,No. 388, Yuhangtang Road,Hangzhou,310058,China; 3.Department of Surgical Oncology,First-Affiliated Hospital,Wenzhou Medical University,No. 2, Fuxue Road,Wenzhou,325000,China; 4.Department of Infection,Taizhou Hospital,Wenzhou Medical University,Taizhou,China
第一作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
第一作者的第一单位	附属台州医院（浙江省台州医院）
推荐引用方式 GB/T 7714	Shen, Xiaokun,Yan, Xingqiang,Xie, Bojian,et al. Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: An updated meta-analysis[J]. AUTOIMMUNITY,2015,48(2):129-135.
APA	Shen, Xiaokun., Yan, Xingqiang., Xie, Bojian., Xu, Dong., Wang, Kuifeng., ... & Cao, Feilin. (2015). Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: An updated meta-analysis. AUTOIMMUNITY, 48(2), 129-135.
MLA	Shen, Xiaokun,et al."Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: An updated meta-analysis".AUTOIMMUNITY 48.2(2015):129-135.